ArticleProceedings of the National Academy of Sciences of the United States of America2021
Mammalian sperm hyperactivation regulates navigation via physical boundaries and promotes pseudo-chemotaxis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight.Experimental physiology · 2026Review
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Sperm navigation in humans: a concerted action of multiple means.Communications biology · 2025Review
- A Two-State Random Walk Model of Sperm Search on Confined Domains.Entropy (Basel, Switzerland) · 2025Article
- Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Improving sperm selection strategies for assisted reproduction through closing the knowledge gap in sperm maturation mechanics.Human reproduction open · 2025Review
- Evolutionary Aspects of Sperm Physiology and Its Assessment.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Article
- Flagellar beating forces of human spermatozoa with different motility behaviors.Reproductive biology and endocrinology : RB&E · 2024Article
- Evaluation of women's aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Exploring altered bovine sperm trajectories by sperm tracking in unconfined conditions.Frontiers in veterinary science · 2024Article
- Review
- Human sperm rotate with a conserved direction during free swimming in four dimensions.Journal of cell science · 2023Article
- Adenylate kinase 9 is essential for sperm function and male fertility in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Human sperm cooperate to transit highly viscous regions on the competitive pathway to fertilization.Communications biology · 2023Article
- Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies†.Biology of reproduction · 2023Article
- Ketone Body β-Hydroxy-Butyrate Sustains Progressive Motility in Capacitated Human Spermatozoa: A Possible Role in Natural Fertility.Nutrients · 2023Article
- Multi-Illumination Single-Holographic-Exposure Lensless Fresnel (MISHELF) Microscopy: Principles and Biomedical Applications.Sensors (Basel, Switzerland) · 2023Review
- Lab-on-chip (LoC) application for quality sperm selection: An undelivered promise?Open research Europe · 2023Review
- New horizons in human sperm selection for assisted reproduction.Frontiers in endocrinology · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian sperm migration within the complex and dynamic environment of the female reproductive tract toward the fertilization site requires navigational mechanisms, through which sperm respond to the tract environment and maintain the appropriate swimming behavior. In the oviduct (fallopian tube), sperm undergo a process called "hyperactivation," which involves switching from a nearly symmetrical, low-amplitude, and flagellar beating pattern to an asymmetrical, high-amplitude beating pattern that is required for fertilization in vivo. Here, exploring bovine sperm motion in high-aspect ratio microfluidic reservoirs as well as theoretical and computational modeling, we demonstrate that sperm hyperactivation, in response to pharmacological agonists, modulates sperm-sidewall interactions and thus navigation via physical boundaries. Prior to hyperactivation, sperm remained swimming along the sidewalls of the reservoirs; however, once hyperactivation caused the intrinsic curvature of sperm to exceed a critical value, swimming along the sidewalls was reduced. We further studied the effect of noise in the intrinsic curvature near the critical value and found that these nonthermal fluctuations yielded an interesting "Run-Stop" motion on the sidewall. Finally, we observed that hyperactivation produced a "pseudo-chemotaxis" behavior, in that sperm stayed longer within microfluidic chambers containing higher concentrations of hyperactivation agonists.
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