Evidence map›Paper›PMID 34716264›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Demonstration of the role of cell wall homeostasis in

Bartłomiej Salamaga, Lingyuan Kong, Laia Pasquina-Lemonche, Lucia Lafage, Milena von Und Zur Muhlen, Josie F Gibson, Danyil Grybchuk, Amy K Tooke, Viralkumar Panchal, Elizabeth J Culp and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Effects of an Herbal Formulation Ethanolic Extract onPathogens (Basel, Switzerland) · 2026
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  3. Lauric Acid Microemulsions InhibitFoods (Basel, Switzerland) · 2026
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  4. Article
  5. Review
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  8. Article
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  10. Article
  11. Molecular Basis of Persister Awakening and Lag-Phase Recovery inInternational journal of molecular sciences · 2026
    Review
  12. Outer membrane vesicles fromFrontiers in microbiology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Bisphosphonate-Conjugated Sitafloxacin for Treatment ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  17. Control of morphogenesis during theScience advances · 2025
    Article
  18. Two codependent routes lead to high-level MRSA.Science (New York, N.Y.) · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 4 countries.

Bartłomiej SalamagaSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.ORCID 0000-0001-9157-5800
Lingyuan KongState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.ORCID 0000-0001-9670-1175
Laia Pasquina-LemoncheThe Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield S102TN, United Kingdom.
Lucia LafageSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.ORCID 0000-0002-8105-5083
Milena von Und Zur MuhlenSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.ORCID 0000-0002-7314-9346
Josie F GibsonSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.
Danyil GrybchukCentral European Institute of Technology, Masaryk University, Brno 60177, Czech Republic.
Amy K TookeSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.ORCID 0000-0002-8719-5263
Viralkumar PanchalSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.ORCID 0000-0002-6204-7336
Elizabeth J CulpM. G. DeGroote Institute for Infectious Disease Research, David Braley Centre for Antibiotic Discovery, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S4L8, Canada.
Elizabeth TathamSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.ORCID 0000-0002-1605-0649
Mary E O'KaneDepartment of Physics and Astronomy, University of Sheffield, Sheffield S37RH, United Kingdom.
Thomas E CatleyDepartment of Physics and Astronomy, University of Sheffield, Sheffield S37RH, United Kingdom.ORCID 0000-0002-8919-2701
Stephen A RenshawThe Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield S102TN, United Kingdom.
Gerard D WrightM. G. DeGroote Institute for Infectious Disease Research, David Braley Centre for Antibiotic Discovery, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S4L8, Canada.
Pavel PlevkaCentral European Institute of Technology, Masaryk University, Brno 60177, Czech Republic.ORCID 0000-0003-4215-3315
Per A BulloughSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom.
Aidong HanState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China; ahan@xmu.edu.cn Jamie.Hobbs@sheffield.ac.uk s.foster@sheffield.ac.uk.
Jamie K HobbsThe Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield S102TN, United Kingdom; ahan@xmu.edu.cn Jamie.Hobbs@sheffield.ac.uk s.foster@sheffield.ac.uk.
Simon J FosterSchool of Biosciences, University of Sheffield, Sheffield S102TN, United Kingdom; ahan@xmu.edu.cn Jamie.Hobbs@sheffield.ac.uk s.foster@sheffield.ac.uk.ORCID 0000-0001-7432-7805
University of Sheffield · GBCentral European Institute of Technology · CZMcMaster University · CAXiamen University · CN

Funding

Medical Research Council MR/N002679/1Medical Research Council MR/N02995X/1Medical Research Council MR/R001111/1Medical Research Council MR/S014934/1Wellcome TrustWellcome Trust 212197/Z/19/Z
6 · The paper itself

Abstract

Bacterial cell wall peptidoglycan is essential, maintaining both cellular integrity and morphology, in the face of internal turgor pressure. Peptidoglycan synthesis is important, as it is targeted by cell wall antibiotics, including methicillin and vancomycin. Here, we have used the major human pathogen

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBacterial ProteinsCell WallHomeostasisMethicillinN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanStaphylococcal InfectionsStaphylococcus aureusTeichoic AcidsVancomycinAnti-Bacterial AgentsAnti-Infective AgentsBacterial ProteinsMethicillinN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanTeichoic AcidsVancomycinantibioticscell wallmethicillinpeptidoglycanvancomycin

Identifiers

PMID34716264
PMCPMC8612353
OpenAlexW3209908396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.