Evidence map›Paper›PMID 34716263›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection.

Laura Bashor, Roderick B Gagne, Angela M Bosco-Lauth, Richard A Bowen, Mark Stenglein, Sue VandeWoude

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
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  11. Evolution takes multiple paths to evolvability when facing environmental change.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  15. SARS-CoV-2 outbreak in lions, tigers and hyenas at Denver Zoo.bioRxiv : the preprint server for biology · 2024
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laura BashorDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-8609-1219
Roderick B GagneDepartment of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348.ORCID 0000-0002-4901-5081
Angela M Bosco-LauthDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-7745-2131
Richard A BowenDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-7576-2881
Mark StengleinDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.
Sue VandeWoudeDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; sue.vandewoude@colostate.edu.
Colorado State University · USUniversity of Pennsylvania · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
CSU Infectious Disease Research and Response Training ProgramT32AI162691 · NIAID · COLORADO STATE UNIVERSITY · PI DEAN, GREGG A · 2021 to 2025
$2.1M
NCATS NIH HHS UL1 TR002535NIAID NIH HHS T32 AI162691
6 · The paper itself

Abstract

SARS-CoV-2 spillback from humans into domestic and wild animals has been well documented, and an accumulating number of studies illustrate that human-to-animal transmission is widespread in cats, mink, deer, and other species. Experimental inoculations of cats, mink, and ferrets have perpetuated transmission cycles. We sequenced full genomes of Vero cell-expanded SARS-CoV-2 inoculum and viruses recovered from cats (

Indexed as

Evolution, MolecularSelection, GeneticAnimalsCatsChlorocebus aethiopsCOVID-19DogsFerretsGene FrequencyPetsSARS-CoV-2Vero CellsViral ProteinsViral Proteinscompanion animalshost adaptationSARS-CoV-2spilloverviral variants

Identifiers

PMID34716263
PMCPMC8612357
OpenAlexW3211030057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.