ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.Neuron · 2026Article
- Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model ofbioRxiv : the preprint server for biology · 2026Article
- A semi-automated MEA spike sorting method for high-throughput assessment of cultured neurons.Stem cell reports · 2026Article
- Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons.Cell reports · 2026Article
- Human neuronal networks on micro-electrode arrays as a tool to assess genotype-phenotype correlation in CACNA1A-related disorders.Stem cell reports · 2026Article
- Human Cortical Organoids with a Novel SCN2A Variant Exhibit Hyperexcitability and Differential Responses to Anti-Seizure Compounds.Neuroscience bulletin · 2025Article
- Acrolein-Induced Alterations in Morphology and Stress Resilience in hiPSC-Derived Cortical Neurons.Environmental science & technology · 2025Article
- A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies.bioRxiv : the preprint server for biology · 2025Article
- Transgenic mouse models of sodium and potassium channelopathies in epilepsy: insights into disease mechanisms and therapeutics.Bioscience reports · 2025Review
- Distinct Synaptic Mechanisms DrivebioRxiv : the preprint server for biology · 2025Article
- Precision Therapeutics in Lennox-Gastaut Syndrome: Targeting Molecular Pathophysiology in a Developmental and Epileptic Encephalopathy.Children (Basel, Switzerland) · 2025Review
- Voltage-gated sodium channels in genetic epilepsy: up and down of excitability.Journal of neurochemistry · 2024Review
- An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds.Journal of advanced research · 2024Article
- Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.Molecular psychiatry · 2024Article
- Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.Environment international · 2024Article
- Crosstalk among WEE1 Kinase, AKT, and GSK3 in Nav1.2 Channelosome Regulation.International journal of molecular sciences · 2024Article
- Exploring Kainic Acid-Induced Alterations in Circular Tripartite Networks with Advanced Analysis Tools.eNeuro · 2024Article
- Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy.Brain : a journal of neurology · 2024Article
- Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-FunctionThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Revisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force.Epilepsia · 2023Article
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 2 countries.
Zhefu QueDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Maria I Olivero-AcostaDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Jingliang ZhangDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-2903-1287
Muriel EatonDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Anke M TukkerPurdue Institute for Integrative Neuroscience, Purdue University, Beijing, China, 100191.
Xiaoling ChenDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Jiaxiang WuDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Junkai XieDepartment of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Tiange XiaoDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Kyle WettschurackDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Layan YunisDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
J Marshall ShaferDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.ORCID 0000-0001-7828-3539
James A SchaberPurdue Imaging Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907.
Jean-Christophe RochetDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Aaron B BowmanPurdue Institute for Integrative Neuroscience, Purdue University, Beijing, China, 100191.
Chongli YuanDepartment of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Zhuo HuangDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China, 100191.
Chang-Deng HuDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Darci J TraderDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
William C SkarnesCellular Engineering, The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.
Yang YangDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907 yangyang@purdue.edu.ORCID 0000-0001-6417-3654
Purdue University West Lafayette · USJackson Laboratory · USPeking University · CN
Funding
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MRole and targeting of PRMT5 in prostate cancerR01CA212403 · NCI · PURDUE UNIVERSITY · PI HUANG, JIAOTI, LI, CHENGLONG · 2017 to 2021
$3.0MManganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's DiseaseR01ES031401 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOWMAN, AARON B, HARRISON, FIONA EDITH · 2020 to 2024
$2.7MNeuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum DisorderR01NS117585 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$2.0MNeuronal hyperexcitability and seizures in a Scn2a deficient mouse modelR01NS123154 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$1.9MMonitoring and Manipulating the Activity of the Immunoproteasome with Small MoleculesR01AI150847 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI TRADER, DARCI J · 2020 to 2023
$1.9MRole of endosulfine-alpha expression and phosphorylation in Parkinson's DiseaseR03NS108229 · NINDS · PURDUE UNIVERSITY · PI ROCHET, JEAN-CHRISTOPHE · 2020 to 2021
$220kNCATS NIH HHS UL1 TR002529NCI NIH HHS R01 CA212403NIAID NIH HHS R01 AI150847NIEHS NIH HHS R01 ES031401NINDS NIH HHS R01 NS117585NINDS NIH HHS R01 NS123154NINDS NIH HHS R03 NS108229
Abstract
With the wide adoption of genomic sequencing in children having seizures, an increasing number of
Indexed as
Cerebral CortexEpilepsyGene EditingHumansInduced Pluripotent Stem CellsMutationNAV1.2 Voltage-Gated Sodium ChannelNeuronsNAV1.2 Voltage-Gated Sodium ChannelSCN2A protein, humananticonvulsantepilepsyhiPSCsL1342PSCN2Avoltage-gated sodium channel
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.