Evidence map›Paper›PMID 34715876›Full record

ArticleMalaria journal2021

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda.

Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G Staedke, Teun Bousema

Open access · goldAbstract readCase Reports
In one paragraph

Article in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Combined effect of methanolic extracts ofParasite epidemiology and control · 2025
    Article
  3. Review
  4. Seroprevalence of Arboviruses in a Malaria Hyperendemic Area in Southern Mali.The American journal of tropical medicine and hygiene · 2024
    Article
  5. Article
  6. Article
  7. The Prevalence of HumanTropical medicine and infectious disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Daniel AyoInfectious Diseases Research Collaboration, Kampala, Uganda.
Bakar OdongoInfectious Diseases Research Collaboration, Kampala, Uganda.
Joseph OmaraInfectious Diseases Research Collaboration, Kampala, Uganda.
Chiara AndolinaDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Ole MulderDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Sarah G StaedkeDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Teun BousemaDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. teun.bousema@radboudumc.nl.ORCID http://orcid.org/0000-0003-2666-094X
Infectious Diseases Research Collaboration · UGRadboud University Nijmegen · NLLondon School of Hygiene & Tropical Medicine · GB

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joaniter Immaculate Nankabirwa · 2010 to 2026
$29.3M
bill and melinda gates foundation INDIE OPP1173572h2020 excellent science ERC-CoG 864180h2020 excellent science QUANTUMnational institute of allergy and infectious diseases U19AI089674NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

backgroundPlasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences. CASE PRESENTATION: Here, five cases of Plasmodium malariae infections from Eastern Uganda (aged 2-39 years) are presented. These infections were all initially mistaken for P. falciparum, but Plasmodium schizonts (up to 2080/µL) were identified by microscopy. Clinical signs included history of fever and mild anaemia.

conclusionThese findings highlight the importance of considering non-falciparum species as the cause of clinical malaria. In areas of intense P. falciparum transmission, where rapid diagnostic tests that detect only P. falciparum antigens are commonly used, non-falciparum malaria cases may be missed.

Indexed as

AdolescentAdultFemaleFeverHumansInfantMalariaMalaria, FalciparumMalePlasmodium falciparumPlasmodium malariaeUgandaYoung AdultDiagnosisMicroscopyMisdiagnosisP. falciparumPlasmodium malariaeSchizonts

Identifiers

PMID34715876
PMCPMC8555357
OpenAlexW3209184938

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.