Evidence map›Paper›PMID 34715552›Full record

ArticleComputers in biology and medicine2021

Hemodynamic alternations following stent deployment and post-dilation in a heavily calcified coronary artery: In silico and ex-vivo approaches.

Peshala T Gamage, Pengfei Dong, Juhwan Lee, Yazan Gharaibeh, Vladislav N Zimin, Luis A P Dallan, Hiram G Bezerra, David L Wilson, Linxia Gu

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In one paragraph

Article in Computers in biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peshala T GamageDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, 32901, USA.
Pengfei DongDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, 32901, USA. Electronic address: pdong@fit.edu.
Juhwan LeeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Yazan GharaibehDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Vladislav N ZiminCardiovascular Imaging Core Laboratory, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Luis A P DallanCardiovascular Imaging Core Laboratory, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Hiram G BezerraInterventional Cardiology Center, Heart and Vascular Institute, The University of South Florida, Tampa, FL, 33606, USA.
David L WilsonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Linxia GuDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, 32901, USA. Electronic address: gul@fit.edu.

Funding

Computer assisted coronary artery stent interventionsR01HL143484 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BEZERRA, HIRAM, WILSON, DAVID LYNN · 2018 to 2021
$2.9M
NHLBI NIH HHS R01 HL143484
6 · The paper itself

Abstract

In this work, hemodynamic alterations in a patient-specific, heavily calcified coronary artery following stent deployment and post-dilations are quantified using in silico and ex-vivo approaches. Three-dimensional artery models were reconstructed from OCT images. Stent deployment and post-dilation with various inflation pressures were performed through both the finite element method (FEM) and ex vivo experiments. Results from FEM agreed very well with the ex-vivo measurements, interms of lumen areas, stent underexpansion, and strut malapposition. In addition, computational fluid dynamics (CFD) simulations were performed to delineate the hemodynamic alterations after stent deployment and post-dilations. A pressure time history at the inlet and a lumped parameter model (LPM) at the outlet were adopted to mimic the aortic pressure and the distal arterial tree, respectively. The pressure drop across the lesion, pertaining to the clinical measure of instantaneous wave-free flow ratio (iFR), was investigated. Results have shown that post-dilations are necessary for the lumen gain as well as the hemodynamic restoration towards hemostasis. Malapposed struts induced much higher shear rate, flow disturbances and lower time-averaged wall shear stress (TAWSS) around struts. Post-dilations mitigated the strut malapposition, and thus the shear rate. Moreover, stenting induced larger area of low TAWSS (<0.4 Pa) and lager volume of high shear rate (>2000 s

Indexed as

Coronary VesselsTomography, Optical CoherenceComputer SimulationDilatationHemodynamicsHumansStentsCalcified arteryComputational fluid dynamics (CFD)Finite element method (FEM)HemodynamicsOptical coherence tomography (OCT)Oscillatory shear indexPercutaneous coronary intervention (PCI)Post-dilationRelative residence timeRestenosisShear rateStent expansionStent thrombosisWall shear stress

Identifiers

PMID34715552
PMCPMC8642291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.