Evidence map›Paper›PMID 34715131›Full record

ArticleThe Journal of biological chemistry2021

Designer proteins that competitively inhibit Gα

Mahmud Hussain, Matthew C Cummins, Stuart Endo-Streeter, John Sondek, Brian Kuhlman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. De novo design of stable proteins that efficaciously inhibit oncogenic G proteins.Protein science : a publication of the Protein Society · 2023
    Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahmud HussainDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA.
Matthew C CumminsDepartment of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
Stuart Endo-StreeterDepartment of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
John SondekDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: sondek@med.unc.edu.
Brian KuhlmanDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: bkuhlman@email.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Regulation of Phospholipase CR01GM057391 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONDEK, JOHN E · 1998 to 2021
$6.9M
GPU workstation for deep learning-based protein design and cryo-EM data processingR35GM131923 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRIAN A KUHLMAN · 2019 to 2026
$6.1M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIST32GM007040 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS, ROBERT A · 1985 to 2019
$6.0M
Inhibition of GTPases and G proteins to treat human diseaseR01GM120291 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, RIHE, SONDEK, JOHN E · 2016 to 2019
$1.4M
NCI NIH HHS P30 CA016086NIGMS NIH HHS R01 GM057391NIGMS NIH HHS R01 GM120291NIGMS NIH HHS R35 GM131923NIGMS NIH HHS T32 GM007040
6 · The paper itself

Abstract

During signal transduction, the G protein, Gα

Indexed as

Cloning, MolecularDatabases, ProteinDrug DesignGTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansModels, MolecularPeptidesPhospholipase C betaProtein BindingProtein EngineeringRecombinant ProteinsGTP-Binding Protein alpha Subunits, Gq-G11PeptidesPhospholipase C betaPLCB3 protein, humanRecombinant ProteinscancerGα(q)heterotrimeric G proteinmolecular modelingpeptide interactionphospholipase Cprotein designRosetta molecular modeling program

Identifiers

PMID34715131
PMCPMC8633581
OpenAlexW3208801468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.