ArticleArchives of endocrinology and metabolism2021
Long-term obesity is associated with depression and neuroinflammation.
Article in Archives of endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Impact of high-fat diet and feeding time on daily anxious-like behaviors in aged male rats.Behavioral and brain functions : BBF · 2026Article
- Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty.Frontiers in nutrition · 2026Review
- Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice.Biology of sex differences · 2025Article
- Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences.GeroScience · 2025Article
- Effect of protein-rich diet and the tamarind trypsin inhibitor on behavioral disorders in obese zebrafish.Frontiers in nutrition · 2025Article
- Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation.Frontiers in pharmacology · 2025Article
- Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment.Frontiers in cellular neuroscience · 2024Article
- Dietary phytochemical index and psychological disorders in a large sample of Iranian adults: a population-based study.Journal of health, population, and nutrition · 2023Article
- Obesity-Induced Brain Neuroinflammatory and Mitochondrial Changes.Metabolites · 2023Review
- Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity.Brain communications · 2023Article
- Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study.Frontiers in psychiatry · 2022Article
- Nutritional factors regulating behavior and biological clocks.Archives of endocrinology and metabolism · 2021Article
- Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObesity is characterized by a state of chronic, low-intensity systemic inflammation frequently associated with insulin resistance and dyslipidemia.
methodsGiven that chronic inflammation has been implicated in the pathogenesis of mood disorders, we investigated if chronic obesity that was initiated early in life - lasting through adulthood - could be more harmful to memory impairment and mood fluctuations such as depression.
resultsHere we show that pre-pubertal male rats (30 days old) treated with a high-fat diet (40%) for 8-months gained ~50% more weight when compared to controls, exhibited depression and anxiety-like behaviors but no memory impairment. The prefrontal cortex of the obese rats exhibited an increase in the expression of genes related to inflammatory response, such as NFKb, MMP9, CCl2, PPARb, and PPARg. There were no alterations in genes known to be related to depression.
conclusionLong-lasting obesity with onset in prepuberal age led to depression and neuroinflammation but not to memory impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.