ArticleJournal of thrombosis and haemostasis : JTH2022
Management strategies and clinical outcomes in patients with inferior vena cava thrombosis: Data from GARFIELD-VTE.
Article in Journal of thrombosis and haemostasis : JTH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- The association between the biomarker D-dimer and thrombosis in vein segment 5 among patients with first episode of deep vein thrombosis.Clinics (Sao Paulo, Brazil) · 2026Article
- Venous mechanical thrombectomy for deep vein thrombosis in patients with cancer: a single-center prospective study.Blood vessels, thrombosis & hemostasis · 2026Article
- Systemic immune-inflammation index as a predictor of venous thromboembolism in NSCLC patients treated with ICIs: a retrospective study.BMC pulmonary medicine · 2026Article
- Effect of endovascular management and anticoagulation alone on acute deep venous thrombosis in patients with inferior vena cava thrombosis.Scientific reports · 2025Article
- Development and validation of a nomogram for predicting postoperative venous thromboembolism risk in patients with hepatocellular carcinoma.World journal of gastrointestinal oncology · 2025Article
- Impact of inferior vena cava thrombosis on the prevalence of pulmonary embolism in patients with lower extremity deep vein thrombosis.Scientific reports · 2025Article
- A nomogram predicting venous thromboembolism risk in primary liver cancer patients.Journal of thrombosis and thrombolysis · 2025Article
- A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024Article
- A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China.Cancer medicine · 2024Article
- Incidence and risk factors for inferior vena cava filter thrombosis detected at time of filter retrieval in patients with lower extremity deep vein thrombosis: a multicenter retrospective cohort study.Quantitative imaging in medicine and surgery · 2023Article
- Primary nephrotic syndrome presenting initially as severe abdominal pain.International urology and nephrology · 2023Article
- Nomogram prediction for the risk of venous thromboembolism in patients with lung cancer.Cancer cell international · 2023Article
- Management strategies and clinical outcomes in patients with inferior vena cava thrombosis: Data from GARFIELD-VTE.Journal of thrombosis and haemostasis : JTH · 2022Article
- Risk factors and a predictive model for nonfilter-associated inferior vena cava thrombosis in patients with lower extremity deep vein thrombosis.Frontiers in cardiovascular medicine · 2022Article
- The Diagnostic Value of the Systemic Immune-Inflammation Index for Venous Thromboembolism in Lung Cancer Patients: A Retrospective Study.Mediators of inflammation · 2022Article
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Authors and funding
18 authors at 13 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInferior vena cava (IVC) thrombosis is a rare form of venous thromboembolism (VTE). The optimal treatment strategies and outcomes are unclear in patients with this presentation.
objectiveWe aimed to compare baseline characteristics, treatment patterns and 24-month outcomes in IVC thrombosis patients (n = 100) with lower extremity deep vein thrombosis (LEDVT) patients (n = 7629).
methodsGARFIELD-VTE is a prospective, observational registry of 10 868 patients with objectively diagnosed VTE from 415 sites in 28 countries.
resultsIVC thrombosis patients were younger (51.9 vs. 59.8 years), more frequently had active cancer (26.0% vs. 8.9%) or history of cancer (21.0% vs. 12.2%), and less frequently had recent trauma or surgery than LEDVT patients. IVC thrombosis was more frequently treated with parenteral anticoagulants alone (35.1% vs. 15.9%), whereas patients with LEDVT more commonly received vitamin K antagonists (32.0% vs. 25.8%) or direct oral anticoagulants (49.0% vs. 35.1%). Thrombolysis (11.0% vs. 3.6%) and surgical/mechanical interventions (4.0% vs. 1.4%) were more frequent in IVC thrombosis. At 24-months, the rate per 100 person-years (95% confidence interval) of all-cause mortality was higher in patients with IVC thrombosis than LEDVT (13.28 [8.57-20.58] vs. 4.91 [4.55-5.3]); the incidence of cancer-associated mortality was comparable as was the incidence of VTE recurrence (4.11 [1.85-9.15] vs. 4.18 [3.84-4.55]). Major bleeding was slightly higher in IVC thrombosis (2.03 [0.66-6.31] vs. 1.66 [1.45-1.89]).
conclusionIn summary, IVC thrombosis patients have higher all-cause mortality rates than those with LEDVT, a finding only partly attributable to malignancy.
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