ArticleScience advances2021
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
Abstract read
In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Form and function of actin impacts actin health and aging.iScience · 2026Article
- Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Insect proteins and peptides: preparation, bioactivities, and applications.Food science of animal resources · 2026Article
- Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025Article
- The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation.Nature aging · 2025Article
- Cross-comparison of strains used for mitochondrial imaging inLife science alliance · 2025Article
- Mechanisms of the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans and Mammals and Its Roles in Striated Muscles.Aging and disease · 2024Review
- Mechanical stress through growth on stiffer substrates impacts animal health and longevity inbioRxiv : the preprint server for biology · 2024Article
- Article
- Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span.Aging cell · 2023Article
- Hijacking Cellular Stress Responses to Promote Lifespan.Frontiers in aging · 2022Review
- UPRFrontiers in cell and developmental biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Erica A MoehleDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-4927-0805
Ryo Higuchi-SanabriaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.ORCID 0000-0001-8936-5812
C Kimberly TsuiDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3807-5329
Stefan HomentcovschiDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Kevin M TharpCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-3543-3266
Hanlin ZhangDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9353-6071
Hannah ChiDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Larry JoeDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Mattias de Los Rios RogersDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3879-4526
Arushi SahayDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-8284-8034
Naame KeletDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-7061-2975
Camila BenitezDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-2462-821X
Raz Bar-ZivDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2615-1942
Gilberto GarciaDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9959-650X
Koning ShenDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2607-449X
Phillip A FrankinoDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3909-3422
Robert T SchinzelDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Ophir ShalemDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadephia, PA 191004, USA.
Andrew DillinDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-7427-2629
Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MNeuroendocrine Coordination of Mitochondrial Stress Signaling and ProteostasisR01ES021667 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2012 to 2023
$4.6MThe Perception of Mitochondrial Stress in Receiving CellsR37AG024365 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2011 to 2020
$4.0MThe Collapse of Proteostasis during Aging is Mediated by Cytoskeletal Actin FunctionsR01AG055891 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2017 to 2021
$1.6MPacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600kDissecting the mechanisms that underlie mislocalization and aggregation of RNA binding proteins in neurodegenerative diseasesR03NS111447 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SHALEM, OPHIR · 2019 to 2019
$352kMore than just a load control: cytoskeletal form and function during agingK99AG065200 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HIGUCHI-SANABRIA, RYO · 2020 to 2021
$244kMechanical stress reprograms mitochondrial metabolism to support tumor survival and invasion through the mitochondrial unfolded protein responseF32CA236156 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THARP, KEVIN · 2019 to 2021
$110kNCI NIH HHS F32 CA236156NIA NIH HHS K99 AG065200NIA NIH HHS R01 AG055891NIA NIH HHS R37 AG024365NIEHS NIH HHS R01 ES021667NIH HHS P40 OD010440NIH HHS S10 OD018174NINDS NIH HHS R03 NS111447
Abstract
The dysfunction of mitochondria is associated with the physiological consequences of aging and many age-related diseases. Therefore, critical quality control mechanisms exist to protect mitochondrial functions, including the unfolded protein response of the mitochondria (UPR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.