ArticleEnvironmental science and pollution research international2022
Combined toxicity of polystyrene microplastics and sulfamethoxazole on zebrafish embryos.
Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 56 citations in OpenAlex.
- Combined Toxicity Effects and Health Risks of Microplastics and Multiple Pollutants.Journal of toxicology · 2026Review
- Polyethylene nanoplastics intensify toxicity of potassium clavulanate in African catfish (Clarias gariepinus).Scientific reports · 2025Article
- Combined Toxicity of Microplastics and Antimicrobials on Animals: A Review.Antibiotics (Basel, Switzerland) · 2025Review
- Multi-Omics Platforms Reveal Synergistic Intestinal Toxicity in Tilapia from Acute Co-Exposure to Polystyrene Microplastics, Sulfamethoxazole, and BDE153.International journal of molecular sciences · 2025Article
- Use of cardiac cell cultures from salmonids to measure the cardiotoxic effect of environmental pollutants.Journal of fish diseases · 2025Article
- Biological hazards of micro- and nanoplastic with adsorbents and additives.Frontiers in public health · 2024Review
- Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health.Frontiers in physiology · 2023Review
- Unraveling the potential human health risks from used disposable face mask-derived micro/nanoplastics during the COVID-19 pandemic scenario: A critical review.Environment international · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Despite extensive investigation on the toxicity of microplastics (MPs), an emerging global concern, little is known about the combined toxicity of MPs and co-occurring pollutants in aquatic environments. In this study, the combined toxicity of polystyrene MPs and sulfamethoxazole (SMZ) antibiotics was explored in zebrafish embryos in terms of the developmental, physiological, and endocrine toxicities. Exposure to PS and SMZ induced mortality (rate: 25.0 ± 7.5%) and malformation (rate: 20~35%) at multiple regions and stages of zebrafish development. Physiological toxicity was also induced as shown by the significant decrease in fetal movement (by 31.1~37.0%) and swimming frequency (by 26.9~36.8%) and the increase in heartbeat rate (by 19.0~20.9%). Finally, PS and SMZ exposure also induced extensive endocrine toxicities in zebrafish as confirmed by increases in various biomarkers including vitellogenin, 17β-estradiol, testosterone, and triiodothyronine. The combination index showed that antagonistic effects were present between PS and SMZ toxicity, which slightly decreased their combined toxicity. This study aims to further understand the combined toxicity of MPs and co-occurring pollutants in aquatic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.