Evidence map›Paper›PMID 34714432›Full record

ReviewActa neurochirurgica2022

Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature.

R J Slegers, T A M Bouwens van der Vlis, L Ackermans, A Hoeben, A A Postma, I Compter, J G J Hoeijmakers, J Beckervordersandforth, M P G Broen, O E M G Schijns

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

R J SlegersDepartment of Neurosurgery, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands. r.slegers@student.maastrichtuniversity.nl.ORCID 0000-0003-2537-428X
T A M Bouwens van der VlisDepartment of Neurosurgery, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
L AckermansDepartment of Neurosurgery, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
A HoebenDepartment of Medical Oncology, School for Oncology and Developmental Biology (GROW), Maastricht UMC+, Maastricht, The Netherlands.
A A PostmaDepartment of Radiology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
I CompterDept. of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht UMC+, Maastricht, The Netherlands.
J G J HoeijmakersDepartment of Neurology, Maastricht UMC+, Maastricht, The Netherlands.
J BeckervordersandforthDepartment of Pathology, Maastricht UMC+, Maastricht, The Netherlands.
M P G BroenDepartment of Neurology, Maastricht UMC+, Maastricht, The Netherlands.
O E M G SchijnsDepartment of Neurosurgery, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.

Indexed as

GlioblastomaMyasthenia GravisThymomaThymus NeoplasmsAgedHumansParaneoplastic SyndromesPostoperative ComplicationsBrain tumorGlioblastomaMyasthenia gravisNeuromuscular junctionParaneoplastic neurological syndrome

Identifiers

PMID34714432
PMCPMC8854242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.