ArticleEuropean child & adolescent psychiatry2023
Relationship between cognition and age at onset of first-episode psychosis: comparative study between adolescents, young adults, and adults.
Article in European child & adolescent psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients.European child & adolescent psychiatry · 2026Article
- Prefrontal Circuitry Abnormalities and Cognitive Impairment in Adolescents with Early- Onset Psychosis.Research square · 2026Article
- Evaluation of the Electroconvulsive Therapy's Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography.Schizophrenia bulletin · 2026Article
- Premorbid functioning trajectories and the one-year course of cognitive performance in first-episode psychosis: a cluster analysis in PSYSCAN.Schizophrenia research. Cognition · 2026Article
- Divergent age-related cognitive impairments in first-episode psychosis.Schizophrenia research. Cognition · 2026Article
- The awareness, characterization, and burden of Cognitive Impairment Associated with Schizophrenia (CIAS) in clinical practice: Results from a nationwide survey in Italy.Schizophrenia research. Cognition · 2025Article
- Neuropsychological profiles in first-episodes psychosis and their relationship with clinical, metacognition and social cognition variables.European archives of psychiatry and clinical neuroscience · 2025Article
- Relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia.Pakistan journal of medical sciences · 2025Article
- Productivity costs of schizophrenia spectrum and other psychotic disorders by friction cost and human capital methods: The Northern Finland Birth Cohort 1966.Social psychiatry and psychiatric epidemiology · 2024Article
- Cognitive impairment in adolescent and adult-onset psychosis: a comparative study.Child and adolescent psychiatry and mental health · 2024Article
- Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia.Antioxidants (Basel, Switzerland) · 2023Article
- The age of onset and cognitive impairment at the early stage of schizophrenia.Cognitive neurodynamics · 2023Article
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Authors and funding
19 authors at 6 institutions in 2 countries.
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Abstract
Psychotic disorders typically manifest from late adolescence to early adulthood, and an earlier onset might be associated with greater symptom severity and a worse long-term prognosis. This study aimed to compare the cognitive characteristics of patients with first-episode psychosis (FEP) by their age at onset. We included 298 patients diagnosed with FEP and classified them as having an early onset (EOS), youth onset (YOS), or adult onset (AOS) based on age limits of ≤ 18 years (N = 61), 19-24 years (N = 121), and ≥ 25 years (N = 116), respectively. Socio-demographic and clinical variables included age at baseline, gender, socio-economic status, antipsychotic medication, DSM-IV diagnoses assessed by clinical semi-structured interview, psychotic symptom severity, and age at onset. Neuropsychological assessment included six cognitive domains: premorbid intelligence, working memory, processing speed, verbal memory, sustained attention, and executive functioning. The EOS group had lower scores than the YOS or AOS groups in global cognition, executive functioning, and sustained attention. Although the scores in the YOS group were intermediate to those in the EOS and AOS groups for most cognitive factors, no statistically significant differences were detected between the YOS and AOS groups. Age at onset results in specific patterns of cognitive interference. Of note, impairment appears to be greater with EOS samples than with either YOS or AOS samples. A longitudinal study with a larger sample size is needed to confirm our findings.
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