Evidence map›Paper›PMID 34714124›Full record

ArticleAIDS research and human retroviruses2021

HIV-1 Genetic Diversity and Natural Polymorphisms of the Integrase Gene in Integrase Inhibitor-Naive Patients in Harare, Zimbabwe.

Amanda Madyadi, Milcah Dhoro, Tinei Shamu, Tendai Washaya, Vinie Kouamou, Benjamin Chimukangara, David Katzenstein, Justen Manasa

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Amanda MadyadiDepartment of Molecular Biology, Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID 0000-0002-7500-6699
Milcah DhoroDepartment of Clinical Pharmacology and Department of Medical Microbiology, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe.
Tinei ShamuDepartment of Molecular Biology, Newlands Clinic, Harare, Zimbabwe.
Tendai WashayaDepartment of Molecular Biology, Biomedical Research and Training Institute, Harare, Zimbabwe.
Vinie KouamouDepartment of Clinical Pharmacology and Department of Medical Microbiology, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe.ORCID 0000-0003-3531-7780
Benjamin ChimukangaraCentre for the AIDS Programme of Research in South Africa, Durban, South Africa.
David KatzensteinDepartment of Molecular Biology, Biomedical Research and Training Institute, Harare, Zimbabwe.
Justen ManasaDepartment of Clinical Pharmacology and Department of Medical Microbiology, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe.
University of Zimbabwe · ZWBiomedical Research and Training Institute · ZWCentre for the AIDS Programme of Research in South Africa · ZAUniversity of Bern · CH

Funding

Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and PathogenesisD43TW011326 · FIC · BIOMEDICAL RESEARCH & TRAINING INSTITUTE · PI MUNYATI, SHUNGU · 2020 to 2024
$1.6M
FIC NIH HHS D43 TW011326
6 · The paper itself

Abstract

Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have become part of the preferred antiretroviral therapy (ART) first-line regimen in most low- to middle-income countries. With the extensive use of dolutegravir in first-line ART, drug resistance mutations to INSTIs are inevitable. Therefore, active monitoring and surveillance of INSTI drug resistance is required. The aim of this study was to evaluate the genetic diversity of the

Indexed as

HIV-1HIV InfectionsHIV IntegraseHIV Integrase InhibitorsDrug Resistance, ViralGenotypeHumansMutationPhylogenyPolymorphism, GeneticZimbabweHIV IntegraseHIV Integrase InhibitorsHIV-1 integrase geneintegrase strand transfer inhibitorsnatural polymorphismspretreatment drug resistanceZimbabwe

Identifiers

PMID34714124
PMCPMC8817709
OpenAlexW3209741373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.