Evidence map›Paper›PMID 34714114›Full record

ArticleAntioxidants & redox signaling2022

Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension.

Aleksandr E Vendrov, Mark D Stevenson, Andrey Lozhkin, Takayuki Hayami, Nathan A Holland, Xi Yang, Nicholas Moss, Hua Pan, Samuel A Wickline, James D Stockand and 3 more

Abstract read
In one paragraph

Article in Antioxidants & redox signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Aging-AssociatedJournal of the American Heart Association · 2026
    Article
  3. SARS-CoV-2 N protein induces hypokalemia in acute kidney injury mice via ENaC-dependent mechanism.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  4. Modulation of Redox-Sensitive Cardiac Ion Channels.Antioxidants (Basel, Switzerland) · 2025
    Review
  5. Reactive oxygen species in hypertension.Nature reviews. Cardiology · 2025
    Review
  6. Article
  7. Review
  8. Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aleksandr E VendrovDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4971-8040
Mark D StevensonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Andrey LozhkinDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Takayuki HayamiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Nathan A HollandDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Xi YangDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Nicholas MossDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Hua PanDepartment of Cardiovascular Sciences, University of South Florida, Tampa, Florida, USA.
Samuel A WicklineDepartment of Cardiovascular Sciences, University of South Florida, Tampa, Florida, USA.
James D StockandDepartment of Cellular and Integrative Physiology, University of Texas Health Science Centre at San Antonio, San Antonio, Texas, USA.
Marschall S RungeDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Nageswara R MadamanchiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-0590-0908
William J ArendshorstDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingAngiotensin IIEpithelial Sodium ChannelsHypertensionNADPH Oxidase 1AnimalsFemaleKidneyMaleMiceSodiumAdaptor Proteins, Signal TransducingAngiotensin IIEpithelial Sodium ChannelsNADPH Oxidase 1NOX1 protein, mouseNoxa1 protein, mouseSodiumepithelial sodium channelshypertensionkidneyreactive oxygen speciessex differencetubular epithelial cells

Identifiers

PMID34714114
PMCPMC8978567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.