ArticleEquine veterinary journal2022
Variation in insulin response to oral sugar test in a cohort of horses throughout the year and evaluation of risk factors for insulin dysregulation.
Article in Equine veterinary journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- High molecular weight adiponectin as an adjunct biomarker for insulin dysregulation in equids.Journal of veterinary internal medicine · 2026Article
- Prevalence of insulin dysregulation in a sport horse population as determined by traditional and stall-side testing.Equine veterinary journal · 2026Article
- Evaluation of the tolerance and effects of 1-deoxynojirimycin on insulin and glucose dynamics in healthy horses and horses at risk for insulin dysregulation.Journal of veterinary internal medicine · 2026Article
- Assessment of baseline adrenocorticotropic hormone and insulin concentrations in healthy horses in Saskatchewan over a 1-year period.Journal of veterinary internal medicine · 2026Article
- Quantitative proteomics unveils potential plasma biomarkers and provides insights into the pathophysiological mechanisms underlying equine metabolic syndrome.BMC veterinary research · 2025Article
- Faecal microbiota and serum metabolome association with equine metabolic syndrome in connemara ponies.BMC veterinary research · 2025Article
- Sodium-glucose transport protein 2 inhibitor use in the management of insulin dysregulation in ponies and horses.Journal of veterinary pharmacology and therapeutics · 2025Review
- Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors.Open veterinary journal · 2023Article
- Predictors of laminitis development in a cohort of nonlaminitic ponies.Equine veterinary journal · 2023Article
- The effects of obesity and insulin dysregulation on mare reproduction, pregnancy, and foal health: a review.Frontiers in veterinary science · 2023Review
- Variation in insulin response to oral sugar test in a cohort of horses throughout the year and evaluation of risk factors for insulin dysregulation.Equine veterinary journal · 2022Article
- The Seasonality of Serum Insulin Concentrations in Equids and the Association With Breed, Age, and Sex.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe oral sugar test (OST) is commonly used to diagnose insulin dysregulation (ID) and equine metabolic syndrome; however, possible seasonal changes in OST results have not been evaluated.
objectiveTo determine the possible variation in insulin response to OST throughout the year and risk factors associated with maximum insulin concentration (InsMax) and ID. STUDY
designProspective, longitudinal cohort study.
methodsThe OST was performed on 29 Finnhorses every other month six times. Serum total adiponectin concentration and phenotypic variables related to obesity were also measured. Changes in InsMax, adiponectin, scale weight, body condition score, cresty neck score (CNS), and fasting glucose concentration were assessed. Risk factor analyses were performed on InsMax and ID status, and ID groups were compared with each other.
resultsFourteen horses were categorised with non-ID each time and 15 as having ID at least once during the follow-up period. The ID status of 12 horses varied throughout the year, but neither the insulin variables measured during the OST nor adiponectin expressed significant seasonal variation. Increasing age and CNS, and decreasing adiponectin were observed as risk factors for a high InsMax after OST. The risk of ID was higher in horses with no exercise compared to horses with exercise (OR 7.6, 95% CI 1.2-49.3, P = .03). Horses with ID had lower serum adiponectin concentrations, longer neck circumference and larger height than horses in the non-ID group. MAIN LIMITATIONS: The environmental conditions (feeding, exercise) were not constant for all horses throughout the study and only one breed was used.
conclusionsNeither OST results nor adiponectin varies with season; however, there were a substantial number of horses with variable ID status throughout the year, in which repeated OSTs may be beneficial. Lack of exercise was a risk factor for ID.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.