ArticleeLife2021
Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Single-cell imaging reveals a key role of Bck2 in yeast cell size adaptation to nutrient challenges.The Journal of cell biology · 2026Article
- uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast.EMBO reports · 2026Article
- The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast.bioRxiv : the preprint server for biology · 2026Article
- A MAP kinase cascade modulates expression of late G1 phase cyclins in budding yeast.bioRxiv : the preprint server for biology · 2025Article
- A growing problem: The many unsolved mysteries of cell growth.Molecular biology of the cell · 2025Review
- MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells.Science signaling · 2025Article
- Cell growth and nutrient availability control the mitotic exit signaling network in budding yeast.The Journal of cell biology · 2024Article
- Modeling the START transition in the budding yeast cell cycle.PLoS computational biology · 2024Article
- Whi5 hypo- and hyper-phosphorylation dynamics control cell-cycle entry and progression.Current biology : CB · 2024Article
- Evidence for novel mechanisms that control cell-cycle entry and cell size.Molecular biology of the cell · 2024Article
- Article
- TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression.International journal of molecular sciences · 2023Review
- Hyperactive Ras disrupts cell size control and a key step in cell cycle entry in budding yeast.Genetics · 2023Article
- Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth.Nature metabolism · 2023Article
- PKA regulatory subunit Bcy1 couples growth, lipid metabolism, and fermentation during anaerobic xylose growth in Saccharomyces cerevisiae.PLoS genetics · 2023Article
- Novel determinants of cell size homeostasis in the opportunistic yeast Candida albicans.Current genetics · 2023Article
- Nutrient availability as an arbiter of cell size.Trends in cell biology · 2022Review
- TOR complex 2 is a master regulator of plasma membrane homeostasis.The Biochemical journal · 2022Article
- The G1/S repressor WHI5 is expressed at similar levels throughout the cell cycle.BMC research notes · 2022Article
- Mad3 modulates the GScience advances · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Entry into the cell cycle occurs only when sufficient growth has occurred. In budding yeast, the cyclin Cln3 is thought to initiate cell cycle entry by inactivating a transcriptional repressor called Whi5. Growth-dependent changes in the concentrations of Cln3 or Whi5 have been proposed to link cell cycle entry to cell growth. However, there are conflicting reports regarding the behavior and roles of Cln3 and Whi5. Here, we found no evidence that changes in the concentration of Whi5 play a major role in controlling cell cycle entry. Rather, the data suggest that cell growth triggers cell cycle entry by driving an increase in the concentration of Cln3. We further found that accumulation of Cln3 is dependent upon homologs of mammalian SGK kinases that control cell growth and size. Together, the data are consistent with models in which Cln3 is a crucial link between cell growth and the cell cycle.
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Registered trials
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