Evidence map›Paper›PMID 34713722›Full record

ArticleJournal of the American Heart Association2021

Influence of

Yan-Ling Liu, Xiao-Lei Hu, Pei-Yuan Song, He Li, Mu-Peng Li, Yin-Xiao Du, Mo-Yun Li, Qi-Lin Ma, Li-Ming Peng, Ming-Yu Song and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Recent research progress on the mechanisms of clopidogrel resistance.European journal of clinical pharmacology · 2026
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  14. Research and practice in thrombosis and haemostasis · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yan-Ling LiuDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Xiao-Lei HuDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Pei-Yuan SongDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
He LiDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Mu-Peng LiDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Yin-Xiao DuDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Mo-Yun LiDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Qi-Lin MaDepartment of Cardiovascular Medicine Xiangya HospitalCentral South University Changsha Hunan China.
Li-Ming PengDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Ming-Yu SongDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.
Xiao-Ping ChenDepartment of Clinical Pharmacology Xiangya HospitalCentral South University Changsha Hunan China.ORCID 0000-0002-2910-9152
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Dual antiplatelet therapy based on aspirin and P2Y12 receptor antagonists such as clopidogrel is currently the primary treatment for coronary artery disease (CAD). However, a percentage of patients exhibit clopidogrel resistance, in which genetic factors play vital roles. This study aimed to investigate the roles of GAS5 (growth arrest-specific 5) and its rs55829688 polymorphism in clopidogrel response in patients with CAD. Methods and Results A total of 444 patients with CAD receiving dual antiplatelet therapy from 2017 to 2018 were enrolled to evaluate the effect of

Indexed as

Coronary Artery DiseaseClopidogrelCytochrome P-450 CYP2C19HumansMicroRNAsPlatelet Aggregation InhibitorsTiclopidineClopidogrelCytochrome P-450 CYP2C19MicroRNAsMIR223, humanPlatelet Aggregation InhibitorsTiclopidineclopidogrelcoronary artery diseaseGAS5miR‐223‐3pP2Y12rs55829688

Identifiers

PMID34713722
PMCPMC8751826
OpenAlexW3210380698

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.