Evidence map›Paper›PMID 34713710›Full record

ArticleJournal of the American Heart Association2021

Blood-Based Epigenetic Markers of

Kento Wada, Tomofumi Misaka, Tetsuro Yokokawa, Yusuke Kimishima, Takashi Kaneshiro, Masayoshi Oikawa, Akiomi Yoshihisa, Yasuchika Takeishi

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. Differential transcriptomic and metabolomic landscape between human hearts donated after cardiac vs brain death.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Methylations in dilated cardiomyopathy and heart failure.Frontiers in cardiovascular medicine · 2025
    Review
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kento WadaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.
Tomofumi MisakaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0003-4795-9334
Tetsuro YokokawaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0001-8197-3274
Yusuke KimishimaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.
Takashi KaneshiroDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0002-5284-9538
Masayoshi OikawaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.
Akiomi YoshihisaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0001-5574-6617
Yasuchika TakeishiDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0002-1188-4708
Fukushima Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Blood-based DNA methylation patterns are linked to types of diseases. FKBP prolyl isomerase 5 (FKBP5), a protein cochaperone, is known to be associated with the inflammatory response, but the regulatory mechanisms by leukocyte

Indexed as

Cardiomyopathy, DilatedDNADNA MethylationDNA Methyltransferase 3AEpigenesis, GeneticHumansRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding ProteinsDNADNA Methyltransferase 3ARNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding Proteinsbiomarkerdilated cardiomyopathyDNA methylationepigeneticsFKBP5

Identifiers

PMID34713710
PMCPMC8751844
OpenAlexW3209851355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.