ArticleJournal of the American Heart Association2021
Long-Term Medication Adherence Trajectories to Direct Oral Anticoagulants and Clinical Outcomes in Patients With Atrial Fibrillation.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Medication adherence trajectories and clinical outcomes in patients with cardiovascular disease: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Atrial Fibrillation and the Risk of Early-Onset Dementia: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Smartphone App for Improving Self-Awareness of Adherence to Edoxaban Treatment in Patients With Atrial Fibrillation (ADHERE-App Trial): Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Discontinuation of oral anticoagulants is common after catheter ablation in older patients with atrial fibrillation.European heart journal open · 2026Article
- Race, Ethnicity, and Language Concordance Between Patients and Physicians and Atrial Fibrillation DOAC Treatment.JAMA network open · 2026Article
- AI-generated patient information leaflets for oral anticoagulants: quality, usability, readability, and reproducibility compared with FDA-referenced materials.International journal of clinical pharmacy · 2026Article
- Etiology and management of venous thromboembolism recurrence in patients anticoagulated for venous thromboembolism: a single-center study.Research and practice in thrombosis and haemostasis · 2026Article
- Article
- Validation of electronic health record-based International Society on Thrombosis and Haemostasis bleeding algorithms in a US health system.Research and practice in thrombosis and haemostasis · 2026Article
- Medication Adherence and Antithrombotic Therapy Outcomes: Insights From a Post Hoc Analysis of the AFIRE Trial.JACC. Asia · 2026Article
- Medication adherence trajectories and association with risk factors and clinical outcomes in type 2 diabetes treatment.PloS one · 2026Article
- Adherence to oral thromboprophylaxis in atrial fibrillation: an overview for clinicians.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Combined Percutaneous Left Atrial Appendage Closure and Mitral Transcatheter Edge-to-Edge Repair: Current Evidence and Practical Considerations.Journal of the American Heart Association · 2025Review
- Ischemic Stroke in Patients Under Oral Anticoagulation: The Achilles Heel of Atrial Fibrillation Management.Brain sciences · 2025Review
- Prediction of long-term adherence to direct oral anti-coagulants in patients with atrial fibrillation using first-order Markov models.Frontiers in pharmacology · 2025Article
- Contemporary National Incidence and Outcomes of Acute Limb Ischemia.Annals of vascular surgery · 2025Article
- Real-world adherence trajectories to direct oral anticoagulants in naive patients with atrial fibrillation in Spain.Frontiers in pharmacology · 2025Article
- DOACs: role of anti-Xa and drug level monitoring.Hematology. American Society of Hematology. Education Program · 2024Review
- Atrial Fibrillation and Other Cardiovascular Factors and the Risk of Dementia: An Italian Case-Control Study.International journal of environmental research and public health · 2024Article
- Predictors of adherence to direct oral anticoagulants after cardiovascular or bleeding events in Medicare Advantage Plan enrollees with atrial fibrillation.Journal of managed care & specialty pharmacy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Background Direct oral anticoagulants (DOACs) are widely used in patients with nonvalvular atrial fibrillation for stroke prevention. However, long-term adherence to DOACs and clinical outcomes in real-world clinical practice is not well understood. This study evaluated long-term medication adherence patterns to DOAC therapy and clinical outcomes in a large US integrated health care system. Methods and Results We included adult patients with nonvalvular atrial fibrillation who newly initiated DOACs between 2012 and 2018 in Kaiser Permanente Southern California. Long-term (3.5 years) adherence trajectories to DOAC were investigated using monthly proportion of days covered and group-based trajectory models. Factors associated with long-term adherence trajectories were investigated. Multivariable Poisson regression analyses were used to investigate thromboembolism and major bleeding events associated with long-term adherence trajectories. Of 18 920 patients newly initiating DOACs, we identified 3 DOAC adherence trajectories: consistently adherent (85.2%), early discontinuation within 6 months (10.6%), and gradually declining adherence (4.2%). Predictors such as lower CHA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.