ArticleMicrobiologyOpen2021
Metagenomic strategies identify diverse integron-integrase and antibiotic resistance genes in the Antarctic environment.
Article in MicrobiologyOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Widespread horizontal transfer and strong selection enhance microbial adaptation in Antarctic soils.Nature communications · 2026Article
- Article
- Network analysis of antimicrobial resistance inNAR genomics and bioinformatics · 2025Article
- Dataset of 569 metagenome-assembled genomes from the caeca of multiple chicken breeds from commercial and backyard farming setups of Pakistan.Data in brief · 2024Article
- Characterization of antibiotic resistance genes and mobile genetic elements in Escherichia coli isolated from captive black bears.Scientific reports · 2024Article
- Phenotypic and resistome analysis of antibiotic and heavy metal resistance in the Antarctic bacterium Pseudomonas sp. AU10.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- A Class 4-like Chromosomal Integron Found inMicroorganisms · 2023Article
- Glacier-Fed Stream Biofilms Harbor Diverse Resistomes and Biosynthetic Gene Clusters.Microbiology spectrum · 2023Article
- Integrons in the development of antimicrobial resistance: critical review and perspectives.Frontiers in microbiology · 2023Review
- Identification and Evolutionary Relationship ofPathogens (Basel, Switzerland) · 2022Article
- Novel Mobile Integrons and Strain-Specific Integrase Genes withinMicroorganisms · 2022Article
- Review
- The Natural History of Integrons.Microorganisms · 2021Review
- Metagenomic strategies identify diverse integron-integrase and antibiotic resistance genes in the Antarctic environment.MicrobiologyOpen · 2021Article
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to identify and analyze integrons and antibiotic resistance genes (ARGs) in samples collected from diverse sites in terrestrial Antarctica. Integrons were studied using two independent methods. One involved the construction and analysis of intI gene amplicon libraries. In addition, we sequenced 17 metagenomes of microbial mats and soil by high-throughput sequencing and analyzed these data using the IntegronFinder program. As expected, the metagenomic analysis allowed for the identification of novel predicted intI integrases and gene cassettes (GCs), which mostly encode unknown functions. However, some intI genes are similar to sequences previously identified by amplicon library analysis in soil samples collected from non-Antarctic sites. ARGs were analyzed in the metagenomes using ABRIcate with CARD database and verified if these genes could be classified as GCs by IntegronFinder. We identified 53 ARGs in 15 metagenomes, but only four were classified as GCs, one in MTG12 metagenome (Continental Antarctica), encoding an aminoglycoside-modifying enzyme (AAC(6´)acetyltransferase) and the other three in CS1 metagenome (Maritime Antarctica). One of these genes encodes a class D β-lactamase (blaOXA-205) and the other two are located in the same contig. One is part of a gene encoding the first 76 amino acids of aminoglycoside adenyltransferase (aadA6), and the other is a qacG2 gene.
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