ReviewJournal of neuroendocrinology2021
The oxytocin system and early-life experience-dependent plastic changes.
Review in Journal of neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- Early life adversity, oxytocin system alterations, and addiction vulnerability: a narrative review.Psychopharmacology · 2026Review
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
- Early life adversity impairs visually evoked innate defensive behaviors via oxytocin signaling.Communications biology · 2026Article
- Oxytocin attenuates isolation-evoked emotional and social behavioral dysregulation through neural, immune, and microbiota mechanisms.Translational psychiatry · 2026Article
- Early Life Mild Adversity Affects in a Sexually Dimorphic Way the Oxytocinergic System Reducing Close Social Interaction in Adult Male Rats.Journal of neurochemistry · 2025Article
- Salivary Oxytocin Levels in Children With and Without Autism: Group Similarities and Subgroup Variability.Journal of clinical medicine · 2025Article
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- Where's my mom? Resilient maternal preference in post-weaning male and female mice within a multi-chamber social behavior task.Brain, behavior, & immunity - health · 2025Article
- Repetitive daily oxytocin treatment reduces weight gain but not acute neonatal procedural pain.Pediatric research · 2025Article
- The Promise of Intranasal Oxytocin in Treating Borderline Personality Disorder: A Narrative Review.Brain sciences · 2025Review
- Oxytocin facilitates human touch-induced play behavior in rats.Current biology : CB · 2025Article
- The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder.Current issues in molecular biology · 2025Review
- AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential temporal decline of cerebral oxytocin and μ-opioid receptor density during the aging process in mice.The European journal of neuroscience · 2024Article
- Is Oxytocin Induction at Labor a Risk Factor for Developmental Hip Dysplasia?Journal of clinical medicine · 2024Article
- Review
- Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety.Comprehensive psychoneuroendocrinology · 2024Article
- New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care.Frontiers in psychology · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early-life experience influences social and emotional behaviour in adulthood. Affiliative tactile stimuli in early life facilitate the development of social and emotional behaviour, whereas early-life adverse stimuli have been shown to increase the risk of various diseases in later life. On the other hand, oxytocin has been shown to have organizational actions during early-life stages. However, the detailed mechanisms of the effects of early-life experience and oxytocin remain unclear. Here, we review the effects of affiliative tactile stimuli during the neonatal period and neonatal oxytocin treatment on the activity of the oxytocin-oxytocin receptor system and social or emotional behaviour in adulthood. Both affiliative tactile stimuli and early-life adverse stimuli in the neonatal period acutely activate the oxytocin-oxytocin receptor system in the brain but modulate social behaviour and anxiety-related behaviour apparently in an opposite direction in adulthood. Accumulating evidence suggests that affiliative tactile stimuli and exogenous application of oxytocin in early-life stages induce higher activity of the oxytocin-oxytocin receptor system in adulthood, although the effects are dependent on experimental procedures, sex, dosages and brain regions examined. On the other hand, early-life stressful stimuli appear to induce reduced activity of the oxytocin-oxytocin receptor system, possibly leading to adverse actions in adulthood. It is possible that activation of a specific oxytocin system can induce beneficial actions against early-life maltreatments and thus could be used for the treatment of developmental psychiatric disorders.
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