Evidence map›Paper›PMID 34713509›Full record

ArticleAddiction biology2022

Modulation of dopamine release by ethanol is mediated by atypical GABA

Jordan T Yorgason, Hillary A Wadsworth, Elizabeth J Anderson, Benjamin M Williams, James N Brundage, David M Hedges, Alyssa L Stockard, Stephen T Jones, Summer B Arthur, David Micah Hansen and 5 more

Open access · greenAbstract read
In one paragraph

Article in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  7. Current neuropharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Jordan T YorgasonDepartment of Cellular Biology and Physiology, Brigham Young University, Provo, Utah, USA.ORCID 0000-0002-5687-0676
Hillary A WadsworthDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
Elizabeth J AndersonDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
Benjamin M WilliamsDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
James N BrundageDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
David M HedgesEnterprise Information Management, Billings Clinic, Billings, Montana, USA.
Alyssa L StockardDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
Stephen T JonesDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
Summer B ArthurDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
David Micah HansenDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.
Nathan D SchilatyDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
Eun Young JangResearch Center for Convergence Toxicology, Korea Institute of Toxicology, Daejeon, South Korea.
Anna M LeeDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4551-0082
Martin WallnerDepartment of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, USA.
Scott C SteffensenDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA.ORCID 0000-0001-6463-8861
Brigham Young University · USBillings Clinic · USKorea Institute of Toxicology · KRMayo Clinic · USUniversity of California, Los Angeles · USUniversity of Minnesota · US

Funding

Nicotine and Alcohol Co-DependenceR01DA035958 · NIDA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2014 to 2018
$2.0M
Dissecting nicotinic receptor contributions to alcohol aversionR01AA026598 · NIAAA · UNIVERSITY OF MINNESOTA · PI LEE, ANNA M. · 2018 to 2022
$1.7M
Neuroplasticity with alcohol dependenceR01AA020919 · NIAAA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2012 to 2016
$1.5M
Effects of Isolation Rearing on Dopamine Release and ReuptakeF31AA020439 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YORGASON, JORDAN THOMAS · 2011 to 2013
$92k
NIAAA NIH HHS F31 AA020439NIAAA NIH HHS R01 AA020919NIAAA NIH HHS R01 AA026598NIDA NIH HHS R01 DA035958
6 · The paper itself

Abstract

Previous studies indicate that moderate-to-high ethanol (EtOH) concentrations enhance dopamine (DA) neurotransmission in the mesolimbic DA system from the ventral tegmental area (VTA) and projecting to the nucleus accumbens core (NAc). However, voltammetry studies demonstrate that moderate-to-high EtOH concentrations decrease evoked DA release at NAc terminals. The involvement of γ-aminobutyric acid (GABA) receptors (GABA

Indexed as

AnimalsDopamineEthanolGABA AgonistsGABA AntagonistsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNucleus AccumbensReceptors, GABADopamineEthanolGABA AgonistsGABA AntagonistsReceptors, GABAaccumbensalcoholcholinergicdopamineGABAnicotinic

Identifiers

PMID34713509
PMCPMC10287192
OpenAlexW3209187096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.