ArticleEuropean radiology2022
Diagnostic accuracy of quantitative dual-energy CT-based volumetric bone mineral density assessment for the prediction of osteoporosis-associated fractures.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Comparative effectiveness of four techniques for identifying vertebral fragility fractures among elderly patients.European radiology · 2025Pooled it
- CT image-based biomarkers for opportunistic screening of osteoporotic fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Moth-Eaten Osteolysis of Multiple Foot Bones After a Conservatively Treated "Stable" Ankle Fracture: A Case Report and Literature Review.Clinical case reports · 2026Article
- Knee-specific bone quality assessment for cementless total knee arthroplasty candidate selection: a narrative review.Knee surgery & related research · 2026Review
- "One-stop-shop" medical imaging for osteoporosis and obese patients: a narrative review.Journal of endocrinological investigation · 2026Review
- Prediction of Osteoporosis at the Sacrum Using Opportunistic CT of the Abdomen and Pelvis: A Retrospective Feasibility Study in 277 Patients Comparing CT and QCT Data.Journal of clinical medicine · 2026Article
- Enhanced diagnosis of osteoporosis using vision transformer with lumbar MRI.BMC medical imaging · 2025Article
- Dual-Head Pix2Pix Network for Material Decomposition of Conventional CT Projections with Photon-Counting Guidance.Sensors (Basel, Switzerland) · 2025Article
- Volumetric Bone Mineral Density Assessed by Dual-Energy CT Predicts Bone Strength Suitability for Cementless Total Knee Arthroplasty.Medicina (Kaunas, Lithuania) · 2025Article
- Bone Mineral Density and Intermuscular Fat Derived from Computed Tomography Images Using Artificial Intelligence Are Associated with Fracture Healing.Bioengineering (Basel, Switzerland) · 2025Article
- Bone Mineral Density (BMD) Assessment Using Dual-Energy CT with Different Base Material Pairs (BMPs).Journal of imaging · 2025Article
- Accuracy of artificial intelligence in prediction of osteoporotic fractures in comparison with dual-energy X-ray absorptiometry and the Fracture Risk Assessment Tool: A systematic review.World journal of orthopedics · 2025Article
- Assessing osteoporosis and bone mineral density throughAnnals of nuclear medicine · 2025Article
- Construction of a clinical prediction model for osteoporosis in asymptomatic elderly population based on machine learning algorithm.Frontiers in medicine · 2025Article
- Enhancing the Opportunistic Bone Status Assessment Using Radiomics Based on Dual-Energy Spectral CT Material Decomposition Images.Bioengineering (Basel, Switzerland) · 2024Article
- Using QCT for the prediction of spontaneous age- and gender-specific thoracolumbar vertebral fractures and accompanying distant vertebral fractures.BMC musculoskeletal disorders · 2024Article
- Cyclic testing of standalone ALIF versus TLIF in lumbosacral spines of low bone mineral density: an ex vivo biomechanical study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints.Current osteoporosis reports · 2024Review
- Reproducibility of CT-based opportunistic vertebral volumetric bone mineral density measurements from an automated segmentation framework.European radiology experimental · 2024Article
- Trabecular bone mineral density as measured by thoracic vertebrae predicts incident hip and vertebral fractures: the multi-ethnic study of atherosclerosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the predictive value of volumetric bone mineral density (BMD) assessment of the lumbar spine derived from phantomless dual-energy CT (DECT)-based volumetric material decomposition as an indicator for the 2-year occurrence risk of osteoporosis-associated fractures.
methodsL1 of 92 patients (46 men, 46 women; mean age, 64 years, range, 19-103 years) who had undergone third-generation dual-source DECT between 01/2016 and 12/2018 was retrospectively analyzed. For phantomless BMD assessment, dedicated DECT postprocessing software using material decomposition was applied. Digital files of all patients were sighted for 2 years following DECT to obtain the incidence of osteoporotic fractures. Receiver operating characteristic (ROC) analysis was used to calculate cut-off values and logistic regression models were used to determine associations of BMD, sex, and age with the occurrence of osteoporotic fractures.
resultsA DECT-derived BMD cut-off of 93.70 mg/cm
conclusionsRetrospective DECT-based volumetric BMD assessment can accurately predict the 2-year risk to sustain an osteoporosis-associated fracture in at-risk patients without requiring a calibration phantom. Lower DECT-based BMD values are strongly associated with an increased risk to sustain fragility fractures. KEY POINTS: •Dual-energy CT-derived assessment of bone mineral density can identify patients at risk to sustain osteoporosis-associated fractures with a sensitivity of 85.45% and a specificity of 89.19%. •The DECT-derived BMD threshold for identification of at-risk patients lies above the American College of Radiology (ACR) QCT guidelines for the identification of osteoporosis (93.70 mg/cm
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