Evidence map›Paper›PMID 34713262›Full record

ReviewFrontiers in genome editing2021

Neuronal Cell-type Engineering by Transcriptional Activation.

Songlei Liu, Johannes Striebel, Giovanni Pasquini, Alex H M Ng, Parastoo Khoshakhlagh, George M Church, Volker Busskamp

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in genome editing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Current Situation and Development Prospect of Whole-Genome Screening.International journal of molecular sciences · 2024
    Review
  5. A Survey of Transcription Factors in Cell Fate Control.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Songlei LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, United States.
Johannes StriebelDepartment of Ophthalmology, Medical Faculty, University of Bonn, Bonn, Germany.
Giovanni PasquiniDepartment of Ophthalmology, Medical Faculty, University of Bonn, Bonn, Germany.
Alex H M NgGC Therapeutics, Inc, Cambridge, MA, United States.
Parastoo KhoshakhlaghGC Therapeutics, Inc, Cambridge, MA, United States.
George M ChurchDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, United States.
Volker BusskampDepartment of Ophthalmology, Medical Faculty, University of Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed screening for inducing neuronal differentiation using CRISPR-Cas transcriptional activation (CRISPRa) and open reading frame (ORF) expression. Critical technical parameters of CRISPRa and ORF-based strategies for neuronal programming are presented and discussed. In addition, recent progress on

Indexed as

CRISPRaforward programmingneuronORFtranscription factor

Identifiers

PMID34713262
PMCPMC8525383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.