Evidence map›Paper›PMID 34713181›Full record

ArticleFrontiers in digital health2021

Digital Therapeutics: Exploring the Possibilities of Digital Intervention for Myopia.

Yong Sun Lee, Seung Eun Choi, Jarang Hahm, Myoung Joon Kim, Hyo Sook Bae, Kayoung Yi, Hyun Taek Lim, Joon Young Hyon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in digital health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yong Sun LeeS-Alpha Therapeutics, Inc., Seoul, South Korea.
Seung Eun ChoiS-Alpha Therapeutics, Inc., Seoul, South Korea.
Jarang HahmS-Alpha Therapeutics, Inc., Seoul, South Korea.
Myoung Joon KimS-Alpha Therapeutics, Inc., Seoul, South Korea.
Hyo Sook BaeBlack Kactus LLC., Seattle, WA, United States.
Kayoung YiDepartment of Ophthalmology, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea.
Hyun Taek LimDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea.
Joon Young HyonDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul University Bundang Hospital, Seongnam, South Korea.
Hallym University Kangnam Sacred Heart Hospital · KRSeoul National University Bundang Hospital · KRUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric myopia is increasing globally and has become a major public health issue. However, the mechanism of pediatric myopia is still poorly understood, and there is no effective treatment to prevent its progression. Based on results from animal and clinical studies, certain neuronal-humoral factors (NHFs), such as IGF-1, dopamine, and cortisol may be involved in the progression of pediatric myopia. Digital therapeutics uses evidence-based software as therapeutic interventions and it has the potential to offer innovative treatment strategies for pediatric myopia beyond conventional treatment methods. In this perspective article, we introduce digital therapeutics SAT-001, a software algorithm that modulates the level of NHFs to reduce the progression of pediatric myopia. The proposed mechanism is based on a theoretical hypothesis derived from scientific research and clinical studies and will be further confirmed by evidence generated from clinical studies involving pediatric myopia.

Indexed as

cortisoldigital therapeuticsdopamineIGF-1neuronal-humoral factorspediatric myopiasoftware algorithmsoftware as medical device

Identifiers

PMID34713181
PMCPMC8521975
OpenAlexW3197644488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.