Evidence map›Paper›PMID 34712844›Full record

ArticleSynthetic biology (Oxford, England)2021

High-yield 'one-pot' biosynthesis of raspberry ketone, a high-value fine chemical.

Simon J Moore, Tommaso Tosi, David Bell, Yonek B Hleba, Karen M Polizzi, Paul S Freemont

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic biology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies.Chembiochem : a European journal of chemical biology · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Simon J MooreCentre for Synthetic Biology and Innovation, Imperial College London, South Kensington Campus, London, UK.
Tommaso TosiDepartment of Medicine, Imperial College London, South Kensington Campus, London, UK.
David BellCentre for Synthetic Biology and Innovation, Imperial College London, South Kensington Campus, London, UK.
Yonek B HlebaCentre for Synthetic Biology and Innovation, Imperial College London, South Kensington Campus, London, UK.
Karen M PolizziCentre for Synthetic Biology and Innovation, Imperial College London, South Kensington Campus, London, UK.ORCID https://orcid.org/0000-0001-5435-2667
Paul S FreemontCentre for Synthetic Biology and Innovation, Imperial College London, South Kensington Campus, London, UK.ORCID https://orcid.org/0000-0002-5658-8486
Imperial College London · GBUniversity of Kent · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-free extract and purified enzyme-based systems provide an attractive solution to study biosynthetic strategies towards a range of chemicals. 4-(4-hydroxyphenyl)-butan-2-one, also known as raspberry ketone, is the major fragrance component of raspberry fruit and is used as a natural additive in the food and sports industry. Current industrial processing of the natural form of raspberry ketone involves chemical extraction from a yield of ∼1-4 mg kg

Indexed as

cell-freefine chemicalpolyketidesraspberry ketonesynthetic biology

Identifiers

PMID34712844
PMCPMC8546603
OpenAlexW3190052130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.