Evidence map›Paper›PMID 34712783›Full record

ArticleTransplantation direct2021

Early Graft Loss Following Transplantation From Expanded Criteria Donors.

Nicholas G Larkins, Germaine Wong, David W Johnson, Carmel Hawley, Armando Teixeira-Pinto, Henry Pleass, Helen Pilmore, Wai H Lim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Nicholas G LarkinsDepartment of Nephrology and Hypertension, Perth Children's Hospital, Nedlands, WA, Australia.
Germaine WongCentre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia.
David W JohnsonAustralasian Kidney Trials Network, University of Queensland, Brisbane, Australia.
Carmel HawleyAustralasian Kidney Trials Network, University of Queensland, Brisbane, Australia.
Armando Teixeira-PintoCentre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia.
Henry PleassFaculty of Medicine and Health, University of Sydney Medical School, Sydney, Australia.
Helen PilmoreRenal Unit, Auckland Hospital, Auckland, New Zealand.
Wai H LimSchool of Medicine, University of Western Australia, Perth, Australia.
Children's Hospital at Westmead · AUKidney Health Australia · AUPrincess Margaret Hospital for Children · AUThe University of Queensland · AUThe University of Western Australia · AUUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExpanded criteria donor (ECD) kidneys are associated with higher graft loss rates than standard criteria donor kidneys. We sought to determine factors associated with early graft loss and their discrimination ability for this outcome compared with kidney donor risk index.

methodsData were extracted from the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) for ECD transplants between 1997 and 2014. The primary outcome was early graft loss (all-cause graft loss within 3 y of transplantation). Death-censored graft loss was substituted as a sensitivity analysis. Era-adjusted odds ratios were calculated by multivariable logistic regression for donor, recipient, and transplant factors available at transplantation. Discrimination was assessed by c-statistic, with 95% confidence intervals (CIs) calculated by bootstrapping.

resultsOf 2152 ECD kidney transplants, early graft loss occurred in 406 (19%) and was associated with recipient diabetes, smoking, First Nations recipients, and oliguria. Of factors defining ECD (age, elevated terminal creatinine, hypertension, death from cerebrovascular accident), all but mode of death were associated with early graft loss. The multivariable model, including known donor, recipient, and transplant factors, was moderately good at predicting early graft loss (c-statistic 0.65; 95% CI, 0.62-0.68). Recipient factors (c-statistic 0.62; 95% CI, 0.59-0.65) performed equally well compared with donor factors (c-statistic 0.60; 95% CI, 0.57-0.64) or the kidney donor risk index (c-statistic 0.60; 95% CI, 0.56-0.63).

conclusionsEarly graft loss occurs in approximately one-fifth of ECD kidney transplants. The discriminatory value of commonly used recipient, donor, and transplant factors are approximately comparable and limited.

Identifiers

PMID34712783
PMCPMC8547939
OpenAlexW3209515678

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.