Evidence map›Paper›PMID 34712662›Full record

ArticleFrontiers in cell and developmental biology2021

Detection of Atherosclerosis by Small RNA-Sequencing Analysis of Extracellular Vesicle Enriched Serum Samples.

Alex Hildebrandt, Benedikt Kirchner, Agnes S Meidert, Florian Brandes, Anja Lindemann, Gero Doose, Alexander Doege, Rolf Weidenhagen, Marlene Reithmair, Gustav Schelling and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

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  20. MicroRNAs Regulate Function in Atherosclerosis and Clinical Implications.Oxidative medicine and cellular longevity · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alex HildebrandtDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Benedikt KirchnerDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Agnes S MeidertDepartment of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Florian BrandesDepartment of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Anja LindemannInstitute of Human Genetics, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Gero DooseecSeq Bioinformatics GmbH, Leipzig, Germany.
Alexander DoegeDepartment of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Rolf WeidenhagenDepartment of Vascular Surgery, Klinikum Neuperlach, Muenchen-Kliniken, Munich, Germany.
Marlene ReithmairInstitute of Human Genetics, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Gustav SchellingDepartment of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Michael W PfafflDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Ludwig-Maximilians-Universität München · DETechnical University of Munich · DEMünchen Klinik Neuperlach · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis can occur throughout the arterial vascular system and lead to various diseases. Early diagnosis of atherosclerotic processes and of individual disease patterns would be more likely to be successful if targeted therapies were available. For this, it is important to find reliable biomarkers that are easily accessible and with little inconvenience for patients. There are many cell culture, animal model or tissue studies that found biomarkers at the microRNA (miRNA) and mRNA level describing atherosclerotic processes. However, little is known about their potential as circulating and liquid biopsy markers in patients. In this study, we examined serum-derived miRNA - profiles from 129 patients and 28 volunteers to identify potential biomarkers. The patients had four different atherosclerotic manifestations: abdominal aneurysm (

Indexed as

atherosclerosisbiomarkerextracellular vesiclesgene ontologysmall RNA-sequencing

Identifiers

PMID34712662
PMCPMC8546328
OpenAlexW3206317147

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.