Evidence map›Paper›PMID 34712623›Full record

ArticleFrontiers in cellular and infection microbiology2021

Rapid Increase of Oral Bacteria in Nasopharyngeal Microbiota After Antibiotic Treatment in Children With Invasive Pneumococcal Disease.

Desiree Henares, Muntsa Rocafort, Pedro Brotons, Mariona F de Sevilla, Alex Mira, Cristian Launes, Raul Cabrera-Rubio, Carmen Muñoz-Almagro

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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  9. Editorial:Frontiers in microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Desiree HenaresInstitut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain.
Muntsa RocafortInstitut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain.
Pedro BrotonsInstitut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain.
Mariona F de SevillaCIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
Alex MiraCIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
Cristian LaunesInstitut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain.
Raul Cabrera-RubioTeagasc Food Research Centre (TEAGASC), Moorepark, Fermoy, Ireland.
Carmen Muñoz-AlmagroInstitut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESInstituto de Salud Carlos III · ESUniversitat de Barcelona · ESUniversitat Internacional de Catalunya · ESUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antibiotics are commonly prescribed to young children for treating bacterial infections such as invasive pneumococcal disease (IPD) caused by Methods: We investigated differences in nasopharyngeal microbiota of two groups of children <18 years with IPD: children not exposed to antibiotics before sample collection (n=27) compared to children previously exposed (n=54). Epidemiological/clinical data were collected from subjects, and microbiota was characterized by Illumina sequencing of V3-V4 amplicons of the 16S rRNA gene. Results: Main epidemiological/clinical factors were similar across groups. Antibiotic-exposed patients were treated during a median of 4 days (IQR: 3-6) with at least one beta-lactam (100.0%). Higher bacterial richness and diversity were found in the group exposed to antibiotics. Different streptococcal amplicon sequence variants (ASVs) were differentially abundant across groups: antibiotic use was associated to lower relative abundances of Conclusion: Our results point toward a reduction of

Indexed as

MicrobiotaPneumococcal InfectionsAnti-Bacterial AgentsBacteriaChildChild, PreschoolHumansInfantNasopharynxRNA, Ribosomal, 16SAnti-Bacterial AgentsRNA, Ribosomal, 16Santibioticschildreninvasive pneumococcal disease (IPD)nasopharyngeal microbiotanosocomial bacteriaoral bacteria

Identifiers

PMID34712623
PMCPMC8546175
OpenAlexW3207831515

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.