ArticleFrontiers in oncology2021
Prognostic Nomogram for Liver Metastatic Colon Cancer Based on Histological Type, Tumor Differentiation, and Tumor Deposit: A TRIPOD Compliant Large-Scale Survival Study.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 13 citations in OpenAlex.
- Construction of the survival nomograms for colon cancer patients of different ages based on the SEER database.Journal of cancer research and clinical oncology · 2023Trial
- Development and validation of prediction models for the prognosis of colon cancer with lung metastases: a population-based cohort study.Frontiers in endocrinology · 2023Trial
- A nomogram for predicting progression-free survival in stage III-IV gastric cancer based on post-treatment cholinesterase and C-reactive protein.Journal of gastrointestinal oncology · 2026Article
- Development and Validation of Platelet-Index Based Colorectal Cancer Survival Prognostic Nomogram.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Is Colonoscopy Alone Adequate for Surveillance in Stage I Colorectal Cancer?Cancer research and treatment · 2025Article
- Article
- Prognostic Index for Liver Radiation (PILiR).Current oncology (Toronto, Ont.) · 2024Article
- Survival prediction in sigmoid colon cancer patients with liver metastasis: a prospective cohort study.JNCI cancer spectrum · 2024Article
- Neoadjuvant Statistical Algorithm to Predict Individual Risk of Relapse in Patients with Resected Liver Metastases from Colorectal Cancer.Biomedicines · 2024Article
- Construction and validation of a prognostic nomogram for predicting cancer-specific survival in patients with intermediate and advanced colon cancer after receiving surgery and chemotherapy.Journal of cancer research and clinical oncology · 2023Article
- Risk and prognostic factors in patients with colon cancer with liver metastasis.The Journal of international medical research · 2023Article
- A population-based predictive model identifying optimal candidates for primary and metastasis resection in patients with colorectal cancer with liver metastatic.Frontiers in oncology · 2022Article
- Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database.Frontiers in genetics · 2022Article
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9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA proportional hazard model was applied to develop a large-scale prognostic model and nomogram incorporating clinicopathological characteristics, histological type, tumor differentiation grade, and tumor deposit count to provide clinicians and patients diagnosed with colon cancer liver metastases (CLM) a more comprehensive and practical outcome measure.
methodsUsing the Transparent Reporting of multivariable prediction models for individual Prognosis or Diagnosis (TRIPOD) guidelines, this study identified 14,697 patients diagnosed with CLM from 1975 to 2017 in the Surveillance, Epidemiology, and End Results (SEER) 21 registry database. Patients were divided into a modeling group (n=9800), an internal validation group (n=4897) using computerized randomization. An independent external validation cohort (n=60) was obtained. Univariable and multivariate Cox analyses were performed to identify prognostic predictors for overall survival (OS). Subsequently, the nomogram was constructed, and the verification was undertaken by receiver operating curves (AUC) and calibration curves.
resultsHistological type, tumor differentiation grade, and tumor deposit count were independent prognostic predictors for CLM. The nomogram consisted of age, sex, primary site, T category, N category, metastasis of bone, brain or lung, surgery, and chemotherapy. The model achieved excellent prediction power on both internal (mean AUC=0.811) and external validation (mean AUC=0.727), respectively, which were significantly higher than the American Joint Committee on Cancer (AJCC) TNM system.
conclusionThis study proposes a prognostic nomogram for predicting 1- and 2-year survival based on histopathological and population-based data of CLM patients developed using TRIPOD guidelines. Compared with the TNM stage, our nomogram has better consistency and calibration for predicting the OS of CLM patients.
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