Evidence map›Paper›PMID 34712574›Full record

ArticleMolecular genetics and metabolism reports2021

Impaired neural differentiation of MPS IIIA patient induced pluripotent stem cell-derived neural progenitor cells.

Rebecca J Lehmann, Lachlan A Jolly, Brett V Johnson, Megan S Lord, Ha Na Kim, Jennifer T Saville, Maria Fuller, Sharon Byers, Ainslie L K Derrick-Roberts

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Rebecca J LehmannGenetics and Molecular Pathology, SA Pathology (at the Women's and Children's Hospital), 72 King William Rd, North Adelaide, SA 5006, Australia.
Lachlan A JollyAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Brett V JohnsonAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Megan S LordGraduate School of Biomedical Engineering, UNSW, Sydney, NSW 2052, Australia.
Ha Na KimGraduate School of Biomedical Engineering, UNSW, Sydney, NSW 2052, Australia.
Jennifer T SavilleGenetics and Molecular Pathology, SA Pathology (at the Women's and Children's Hospital), 72 King William Rd, North Adelaide, SA 5006, Australia.
Maria FullerGenetics and Molecular Pathology, SA Pathology (at the Women's and Children's Hospital), 72 King William Rd, North Adelaide, SA 5006, Australia.
Sharon ByersGenetics and Molecular Pathology, SA Pathology (at the Women's and Children's Hospital), 72 King William Rd, North Adelaide, SA 5006, Australia.
Ainslie L K Derrick-RobertsGenetics and Molecular Pathology, SA Pathology (at the Women's and Children's Hospital), 72 King William Rd, North Adelaide, SA 5006, Australia.
University of Adelaide · AUWomen's and Children's Hospital · AUUNSW Sydney · AUSouth Australia Pathology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucopolysaccharidosis type IIIA (MPS IIIA) is characterised by a progressive neurological decline leading to early death. It is caused by bi-allelic loss-of-function mutations in

Indexed as

CNS, central nervous systemFGF, Fibroblast growth factorFibroblast growth factor 2GAG, glycosaminoglycanHeparan sulphate glycosaminoglycanHS, heparan sulphateInduced pluripotent stem cellsiPSC, induced pluripotent stem cellMEF, mouse embryonic fibroblastMPS IIIAMPS IIIA, mucopolysaccharidosis type IIIANeurogenesisNPC, neural progenitor cell

Identifiers

PMID34712574
PMCPMC8531667
OpenAlexW3207832948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.