Evidence map›Paper›PMID 34712555›Full record

ReviewJournal of bone oncology2021

Frequency and reason for reoperation following non-invasive expandable endoprostheses: A systematic review.

Johnathan R Lex, Amirul Adlan, Kim Tsoi, Scott Evans, Jonathan D Stevenson

Open access · goldAbstract readReview
In one paragraph

Review in Journal of bone oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. [Reconstruction of bone defects after resection of osteosarcoma in children with artificial hemi-knee prosthesis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Johnathan R LexThe Royal Orthopaedic Hospital, Oncology Department, Birmingham, West Midlands B31 2AP, UK.
Amirul AdlanThe Royal Orthopaedic Hospital, Oncology Department, Birmingham, West Midlands B31 2AP, UK.
Kim TsoiDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.
Scott EvansThe Royal Orthopaedic Hospital, Oncology Department, Birmingham, West Midlands B31 2AP, UK.
Jonathan D StevensonThe Royal Orthopaedic Hospital, Oncology Department, Birmingham, West Midlands B31 2AP, UK.
Royal Orthopaedic Hospital · GBMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-invasive expandable endoprostheses (NIEPR) utilize an external electromagnetic field to drive an innate mechanical gearbox. This lengthens the extremity following oncological resections in children with a predicted limb length discrepancy (LLD), facilitating limb-salvage. This review was conducted to assess NIEPR implant survival rates and identify modes of implant failure unique to these prostheses.

methodsMedline, EMBASE and the Cochrane Library databases were searched for all manuscripts evaluating implant survival of NIEPRs implanted into skeletally immature patients following resection of extremity sarcomas. Minimum follow-up of 12 months or implant failure was required for inclusion. Failures were classified using the latest ISOLS classification and exact implant-specific failure modality was also identified.

results19 studies met inclusion criteria. Mean age was 10.0 years (7.7 - 11.4 years). The most common locations for NIEPR implantation were the distal femur (343, 76.7%) and proximal tibia (53, 119%). Mean follow-up was 65.3 months (19.4 - 163 months). The overall implant revision rate was 46.2% (0 - 100%); implant specific revisions included maximal prosthesis lengthening with persistent LLD (10.4%), failed extension mechanism (6.1%), implant fracture (7.7%), hinge fracture (1.4%) and bushing wear (0.9%). Persistent clinically significant (>20 mm) LLD at final follow-up was present in 19.2% (0 - 50%) of patients. The mean MSTS score was 85.1% (66.7-96.3%) at final follow-up.

conclusionImplant-related failures are the most common reason for NIEPR revision. Implant reliability appears to be improved with current designs. A sub-classification to the current classification system based on implant-specific failures for NIEPRs is proposed.

Indexed as

Expandable prosthesisLimb-length discrepancyNon-invasiveOrthopaedic oncologyPaediatric tumourSarcoma

Identifiers

PMID34712555
PMCPMC8529098
OpenAlexW3205182700

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.