Evidence map›Paper›PMID 34712235›Full record

ReviewFrontiers in immunology2021

Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development.

Greta Volpedo, Thalia Pacheco-Fernandez, Parna Bhattacharya, Timur Oljuskin, Ranadhir Dey, Sreenivas Gannavaram, Abhay R Satoskar, Hira L Nakhasi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Frontiers in immunology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. iScience · 2023
    Article
  14. Article
  15. iScience · 2023
    Article
  16. Rectal Administration ofTropical medicine and infectious disease · 2023
    Article
  17. Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization.Tropical medicine and infectious disease · 2023
    Review
  18. Article
  19. Functionally distinct regions of the locusFrontiers in immunology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Greta VolpedoDepartments of Pathology and Microbiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Thalia Pacheco-FernandezDepartments of Pathology and Microbiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Parna BhattacharyaLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Timur OljuskinLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Ranadhir DeyLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Sreenivas GannavaramLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Abhay R SatoskarDepartments of Pathology and Microbiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Hira L NakhasiLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Center for Biologics Evaluation and Research · USThe Ohio State University Wexner Medical Center · US

Funding

A live attenuated vaccine for leishmaniasisR21AI130485 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R, ZHIOUA, ELYES · 2018 to 2019
$376k
NIAID NIH HHS R21 AI130485
6 · The paper itself

Abstract

Leishmaniasis is endemic to the tropical and subtropical regions of the world and is transmitted by the bite of an infected sand fly. The multifaceted interactions between

Indexed as

Immunity, InnateVaccine DevelopmentAnimalsCytotoxicity, ImmunologicDendritic CellsHumansImmune EvasionImmunogenicity, VaccineKiller Cells, NaturalLeishmania donovaniLeishmaniasis VaccinesLeishmaniasis, VisceralMacrophagesMast CellsMetabolomicsMiceLeishmaniasis Vaccinesimmune-regulationinnate immunitylive attenuated leishmania vaccinesmetabolic regulationmetabolomicstrained immunityvaccinevisceral leishmaniasis

Identifiers

PMID34712235
PMCPMC8546207
OpenAlexW3205949716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.