Evidence map›Paper›PMID 34712223›Full record

ArticleFrontiers in immunology2021

Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy.

Gabriella Lauriero, Lilia Abbad, Mirco Vacca, Giuseppe Celano, Jonathan M Chemouny, Maria Calasso, Laureline Berthelot, Loreto Gesualdo, Maria De Angelis, Renato C Monteiro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  20. IgA nephropathy: gut microbiome regulates the production of hypoglycosilated IgA1 via the TLR4 signaling pathway.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Gabriella LaurieroCenter for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.
Lilia AbbadCenter for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.
Mirco VaccaDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Giuseppe CelanoDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Jonathan M ChemounyCenter for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.
Maria CalassoDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Laureline BerthelotCenter for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
Maria De AngelisDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Renato C MonteiroCenter for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.
University of Bari Aldo Moro · ITCentre de Recherche sur l'Inflammation · FRCentre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Several observations suggest that gut microbiota could be implicated in IgAN pathophysiology. Aiming at exploring whether microbiota modulation is able to influence disease outcome, we performed fecal microbiota transplantation (FMT) from healthy controls (HC-sbjs), non-progressor (NP-pts) and progressor (P-pts) IgAN patients to antibiotic-treated humanized IgAN mice (α1KI-CD89Tg), by oral gavage. FMT was able to modulate renal phenotype and inflammation. On one hand, the microbiota from P-pts was able to induce an increase of serum BAFF and galactose deficient-IgA1 levels and a decrease of CD89 cell surface expression on blood CD11b

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAnimalsAntigens, CDBacteriaB-Cell Activating FactorCase-Control StudiesDisease Models, AnimalDysbiosisGlomerulonephritis, IGAHumansImmunoglobulin AKidneyMaleMice, TransgenicPhenotypeAntigens, CDB-Cell Activating FactorFc(alpha) receptorImmunoglobulin AReceptors, FcTNFSF13B protein, humanTnfsf13b protein, mouseVolatile Organic CompoundsBAFFfecal microbiota transplantationgut microbiotaIgA nephropathymouse model

Identifiers

PMID34712223
PMCPMC8546224
OpenAlexW3207725325

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.