Evidence map›Paper›PMID 34712146›Full record

ArticleFrontiers in physiology2021

Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice.

Melissa E Heard-Lipsmeyer, Iad Alhallak, Frank A Simmen, Stepan B Melnyk, Rosalia C M Simmen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. The interplay between endometriosis and obesity.Trends in endocrinology and metabolism: TEM · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Melissa E Heard-LipsmeyerDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Iad AlhallakDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Frank A SimmenDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Stepan B MelnykArkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Rosalia C M SimmenDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · USEdward Via College of Osteopathic Medicine · US

Funding

UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENTR01HD021961 · NICHD · UNIVERSITY OF FLORIDA · PI SIMMEN, ROSALIA C · 1991 to 2008
$2.1M
NICHD NIH HHS R01 HD021961
6 · The paper itself

Abstract

Endometriosis is a chronic, estrogen-dependent gynecologic disorder that affects reproductive-aged women and to a lesser extent, post-menopausal women on hormone therapy. The condition is associated with systemic and local immune dysfunctions. While its underlying mechanisms remain poorly understood, endometriosis has a genetic component and propensity for the disease is subject to environmental, nutritional, and lifestyle influences. Previously, we showed that high-fat diet (HFD) increased ectopic lesion numbers, concurrent with systemic and peritoneal changes in inflammatory and oxidative stress status, in immunocompetent recipient mice

Indexed as

endometriosishigh-fat dietinflammationKrüppel-like factor 9oxidative stress

Identifiers

PMID34712146
PMCPMC8547326
OpenAlexW3199165188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.