Evidence map›Paper›PMID 34712101›Full record

ArticleMediators of inflammation2021

Endangered Lymphocytes: The Effects of Alloxan and Streptozotocin on Immune Cells in Type 1 Induced Diabetes.

Luiz A D Queiroz, Josiane B Assis, João P T Guimarães, Emanuella S A Sousa, Anália C Milhomem, Karen K S Sunahara, Anderson Sá-Nunes, Joilson O Martins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Curcumin Mitigates Streptozotocin-Induced GenotoxicityCombinatorial chemistry & high throughput screening · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luiz A D QueirozLaboratory of Immunoendocrinology, School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-3560-3963
Josiane B AssisLaboratory of Experimental Immunology, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0001-6549-912X
João P T GuimarãesLaboratory of Immunoendocrinology, School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-3818-6990
Emanuella S A SousaLaboratory of Immunoendocrinology, School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0001-8861-635X
Anália C MilhomemInstitute of Tropical Pathology and Public Health, Department of Microbiology, Immunology, Parasitology and Pathology, Federal University of Goiás, Goiânia, GO, Brazil.ORCID https://orcid.org/0000-0001-6264-8695
Karen K S SunaharaExperimental Physiopathology, Department of Sciences/Experimental Physiopathology, Medical School, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-2513-0840
Anderson Sá-NunesLaboratory of Experimental Immunology, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0002-1859-4973
Joilson O MartinsLaboratory of Immunoendocrinology, School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-2630-7038
Universidade de São Paulo · BRUniversidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alloxan (ALX) and streptozotocin (STZ) are extensively used to induce type 1 diabetes (T1D) in animal models. This study is aimed at evaluating the differences in immune parameters caused by ALX and STZ. T1D was induced either with ALX or with STZ, and the animals were followed for up to 180 days. Both ALX and STZ induced a decrease in the total number of circulating leukocytes and lymphocytes, with an increase in granulocytes when compared to control mice (CT). STZ-treated mice also exhibited an increase in neutrophils and a reduction in the lymphocyte percentage in the bone marrow. In addition, while the STZ-treated group showed a decrease in total CD3

Indexed as

AlloxanAnimalsBlood GlucoseCytokinesDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1LymphocytesMaleMiceMice, Inbred C57BLPancreasSpleenStreptozocinThymus GlandAlloxanBlood GlucoseCytokinesStreptozocin

Identifiers

PMID34712101
PMCPMC8548114
OpenAlexW3207954400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.