Evidence map›Paper›PMID 34712008›Full record

ReviewJournal of toxicologic pathology2021

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (

Karyn Colman, Rachel N Andrews, Hannah Atkins, Theresa Boulineau, Alys Bradley, Annamaria Braendli-Baiocco, Raffaella Capobianco, David Caudell, Mark Cline, Takuya Doi and 18 more

Abstract readReview
In one paragraph

Review in Journal of toxicologic pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. International journal of medical sciences · 2026
    Article
  4. Integrative Toxicology Profiling ofFood science & nutrition · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Karyn ColmanNovartis Institutes for BioMedical Research, Cambridge, MA, USA.
Rachel N AndrewsWake Forest School of Medicine, Department of Radiation Oncology, Winston-Salem, NC, USA.
Hannah AtkinsPenn State College of Medicine, Department of Comparative Medicine, Hershey, PA, USA.
Theresa BoulineauBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
Alys BradleyCharles River Laboratories Edinburgh Ltd., Tranent, Scotland, UK.
Annamaria Braendli-BaioccoRoche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Switzerland.
Raffaella CapobiancoJanssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.
David CaudellDepartment of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Mark ClineDepartment of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Takuya DoiLSIM Safety Institute Corporation, Ibaraki, Japan.
Rainer ErnstHennigsdorf, Germany.
Eric van EschInSight Pathology BV, Oss, the Netherlands.
Jeffrey EverittDepartment of Pathology, Duke University School of Medicine, Durham, NC, USA.
Pierluigi FantCharles River Laboratories, Lyon, France.
Margarita M GruebbelExperimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA.
Lars MecklenburgCovance Preclinical Services GmbH, Münster, Germany.
Andew D MillerCornell University College of Veterinary Medicine, Ithaca, NY, USA.
Kristen J NikulaInotiv, Maryland Heights, MO, USA.
Shigeru SatakeShin Nippon Biomedical Laboratories, Ltd., Kagoshima and Tokyo, Japan.
Julie SchwartzCharles River Laboratories, Reno, NV, USA.
Alok SharmaCovance Laboratories, Inc., Madison, WI, USA.
Akihito ShimoiIna Research Inc, Nagano, Japan.
Cécile SobryCharles River Laboratories, Evreux, France.
Ian TaylorCovance Laboratories, Ltd., Eye, UK.
Vimala VemireddiCovance Laboratories, Inc., Chantilly, VA, USA.
Justin VidalCharles River, Mattawan, MI, USA.
Charles WoodBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
John L VahleLilly Research Laboratories, Indianapolis IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the nonhuman primate used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

Indexed as

background findingscynomolgus macaqueINHANDnomenclaturenonhuman primatepathologytoxicopathology

Identifiers

PMID34712008
PMCPMC8544165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.