Evidence map›Paper›PMID 34711838›Full record

ArticleNature communications2021

Ion-dependent structure, dynamics, and allosteric coupling in a non-selective cation channel.

Adam Lewis, Vilius Kurauskas, Marco Tonelli, Katherine Henzler-Wildman

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. High-Throughput MicroED for Probing Ion Channel Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam LewisDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Vilius KurauskasDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Marco TonelliNational Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison, Madison, WI, 53706, USA.
Katherine Henzler-WildmanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. henzlerwildm@wisc.edu.ORCID 0000-0002-5295-2121

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4M
NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
Molecular Mechanisms of Channels and TransportersR35GM141748 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$2.7M
CONFORMATIONAL DYNAMICS IN ION CHANNEL SELECTIVITY AND GATINGR01GM116047 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HENZLER-WILDMAN, KATHERINE ANNE · 2015 to 2018
$1.2M
NIGMS NIH HHS P41 GM103399NIGMS NIH HHS R01 GM116047NIGMS NIH HHS R24 GM141526NIGMS NIH HHS R35 GM141748
6 · The paper itself

Abstract

The selectivity filter (SF) determines which ions are efficiently conducted through ion channel pores. NaK is a non-selective cation channel that conducts Na

Indexed as

Allosteric RegulationBacteriaBacterial ProteinsCrystallography, X-RayMagnetic Resonance SpectroscopyMolecular Dynamics SimulationPotassiumPotassium ChannelsSodiumSodium ChannelsBacterial ProteinsPotassiumPotassium ChannelsSodiumSodium Channels

Identifiers

PMID34711838
PMCPMC8553846

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.