ArticleNature communications2021
Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- The Orbitofrontal Cortex Represents the Allocentric Spatial States of Dynamic Agents Within a Static Environmental Framework.Neuroscience bulletin · 2026Article
- Distinct Hippocampal Mechanisms Support Concept Formation and Updating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- The Role of Rapid Eye Movement Sleep in Neural Differentiation of Memories in the Hippocampus.Journal of cognitive neuroscience · 2026Article
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Hippocampal transformations occur along dimensions of memory interference.bioRxiv : the preprint server for biology · 2025Article
- Repulsion of hippocampal representations driven by distinct internal beliefs.Current biology : CB · 2025Article
- Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD.Nature communications · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- A simple model for Behavioral Time Scale Synaptic Plasticity (BTSP) provides content addressable memory with binary synapses and one-shot learning.Nature communications · 2025Article
- Article
- Differentiation and Integration of Competing Memories: A Neural Network Model.bioRxiv : the preprint server for biology · 2024Article
- Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD.bioRxiv : the preprint server for biology · 2024Article
- Event Integration and Temporal Differentiation: How Hierarchical Knowledge Emerges in Hippocampal Subfields through Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hippocampal contributions to novel spatial learning are both age-related and age-invariant.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hippocampal contributions to novel spatial learning are both age-related and age-invariant.bioRxiv : the preprint server for biology · 2023Article
- Structured memory representations develop at multiple time scales in hippocampal-cortical networks.bioRxiv : the preprint server for biology · 2023Article
- Article
- Representations of Complex Contexts: A Role for Hippocampus.Journal of cognitive neuroscience · 2022Article
- Altered hippocampal functional connectivity after the rupture of anterior communicating artery aneurysm.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
When we remember a city that we have visited, we retrieve places related to finding our goal but also non-target locations within this environment. Yet, understanding how the human brain implements the neural computations underlying holistic retrieval remains unsolved, particularly for shared aspects of environments. Here, human participants learned and retrieved details from three partially overlapping environments while undergoing high-resolution functional magnetic resonance imaging (fMRI). Our findings show reinstatement of stores even when they are not related to a specific trial probe, providing evidence for holistic environmental retrieval. For stores shared between cities, we find evidence for pattern separation (representational orthogonalization) in hippocampal subfield CA2/3/DG and repulsion in CA1 (differentiation beyond orthogonalization). Additionally, our findings demonstrate that medial prefrontal cortex (mPFC) stores representations of the common spatial structure, termed schema, across environments. Together, our findings suggest how unique and common elements of multiple spatial environments are accessed computationally and neurally.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.