ArticleTranslational psychiatry2021
Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Exploring subthreshold functional network alterations in women with phenylketonuria by higher criticism.BMC research notes · 2026Article
- Neuroticism heterogeneity through item-level associations in resting-state functional connectivity.Communications biology · 2025Article
- Older and wiser? The neural correlates of worry induction and reappraisal in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The Desegregation of Neural Networks During Worry Induction in Late Life: An Effective Connectivity Analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Network homeostasis: functional brain network alterations and relapse in remitted late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Reduced mind-wandering and fewer depressive symptoms associated with damage to the medial prefrontal cortex and default mode network.Neuropsychologia · 2025Article
- A preliminary investigation of worry, cortical amyloid burden, and stressor-evoked brain and cardiovascular reactivity in older adults.Journal of affective disorders · 2024Article
- Specific Association of Worry With Amyloid-β But Not Tau in Cognitively Unimpaired Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Seeing more than the Tip of the Iceberg: Approaches to Subthreshold Effects in Functional Magnetic Resonance Imaging of the Brain.Clinical neuroradiology · 2024Review
- White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome.BMC medicine · 2023Article
- Cognitive, Disability, and Treatment Outcome Implications of Symptom-Based Phenotyping in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Brain morphometric features predict depression symptom phenotypes in late-life depression using a deep learning model.Frontiers in neuroscience · 2023Article
- Heterogenous Subtypes of Late-Life Depression and Their Cognitive Patterns: A Latent Class Analysis.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Severe worry is a complex transdiagnostic phenotype independently associated with increased morbidity, including cognitive impairment and cardiovascular diseases. We investigated the neurobiological basis of worry in older adults by analyzing resting state fMRI using a large-scale network-based approach. We collected resting fMRI on 77 participants (>50 years old) with varying worry severity. We computed region-wise connectivity across the default mode network (DMN), anterior salience network, and left executive control network. All 22,366 correlations were regressed on worry severity and adjusted for age, sex, race, education, disease burden, depression, anxiety, rumination, and neuroticism. We employed higher criticism, a second-level method of significance testing for rare and weak features, to reveal the functional connectivity patterns associated with worry. The analysis suggests that worry has a complex, yet distinct signature associated with resting state functional connectivity. Intra-connectivities and inter-connectivities of the DMN comprise the dominant contribution. The anterior cingulate, temporal lobe, and thalamus are heavily represented with overwhelmingly negative association with worry. The prefrontal regions are also strongly represented with a mix of positive and negative associations with worry. Identifying the most salient connections may be useful for targeted interventions for reducing morbidity associated with severe worry in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.