ArticleJournal of addiction medicine
Trends in Hospitalizations for Serious Infections Among People With Opioid Use Disorder in Ontario, Canada.
Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Controlled-release hydromorphone and risk of infection in adults: a systematic review.Harm reduction journal · 2023Pooled it
- Harm reduction-focused behavioral activation for people who inject drugs: Mixed methods outcomes from a pilot open trial.Journal of substance use and addiction treatment · 2024Trial
- Recent hydromorphone injection and risk of incident infective endocarditis among people who inject drugs in Toronto, Canada: a cohort study.Harm reduction journal · 2026Article
- Geographic Variations of Intensive Care Unit Admissions with Substance-Related Diagnoses in the United States.Journal of intensive care medicine · 2026Observational
- Health, Costs, and Injection-Related Infections at a Hypothetical Overdose Prevention Center.JAMA network open · 2026Article
- Qualitative analysis of barriers and facilitators to healthcare engagement for people with injecting-related invasive infections using a social ecological framework.Addiction (Abingdon, England) · 2025Article
- Observational
- Association of chronic opioid therapy and opioid use disorder with COVID-19-related hospitalization and mortality: Evidence from three health systems in the United States.Preventive medicine reports · 2024Article
- Social determinants of injection drug use-associated bacterial infections and treatment outcomes: systematic review and meta-analysis.medRxiv : the preprint server for health sciences · 2024Article
- PICC Your Poison: Resident Beliefs and Attitudes Regarding Discharge Parenteral Antibiotics for Patients Who Inject Drugs.Open forum infectious diseases · 2024Article
- Economic evaluation of the effect of needle and syringe programs on skin, soft tissue, and vascular infections in people who inject drugs: a microsimulation modelling approach.Harm reduction journal · 2024Article
- Implementation of pharmaceutical alternatives to a toxic drug supply in British Columbia: A mixed methods study.Journal of substance use and addiction treatment · 2024Article
- Opioid-related deaths between 2019 and 2021 across 9 Canadian provinces and territories.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Article
- Epidemiology of acute infections in people who inject drugs in Australia.Drug and alcohol review · 2024Review
- Opioid Injection-Associated Bacterial Infections in England, 2002-2021: A Time Series Analysis of Seasonal Variation and the Impact of Coronavirus Disease 2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Association of Illicit Fentanyl Use with Injection Risk Practices Among People who Inject Drugs.AIDS and behavior · 2023Article
- Initiations of safer supply hydromorphone increased during the COVID-19 pandemic in Ontario: An interrupted time series analysis.PloS one · 2023Article
- Clinical outcomes and health care costs among people entering a safer opioid supply program in Ontario.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Article
- Characterizing safer supply prescribing of immediate release hydromorphone for individuals with opioid use disorder across Ontario, Canada.The International journal on drug policy · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesOpioid use among people who inject drugs can lead to serious complications, including infections. We sought to study trends in rates of these complications among people with an opioid use disorder (OUD) and the sequelae of those hospitalizations.
methodsWe analyzed all inpatient hospitalizations for serious infections (infective endocarditis [IE], spinal infections, nonvertebral bone infections, and skin or soft tissue infections) among people with OUD in Ontario between 2013 and 2019. We reported the population adjusted rate of hospitalizations for serious infections annually, stratified by type of infection and prevalence of prior opioid agonist therapy and hydromorphone prescribing. We reported characteristics of hospitalizations and 30-day mortality in the most recent 2 years.
resultsAmong people with OUD there was a 167% increase in rates of IE (7.7-20.6 per million residents; P < 0.01), a 394% increase in rates of spinal infections (3.4-16.8 per million residents; P < 0.01), a 191% increase in rates of nonvertebral bone infections (8.9 to 25.9 per million residents; P < 0.01), and a 147% increase in infections of the skin or soft tissue (32.1-79.4 per million residents; P < 0.01) over 7 years in Ontario. Death in-hospital and within 30 days of discharge was highest among those with IE (11.5% and 15.9%, respectively), and lower among those with other infections (<5%).
conclusionsRates of serious infections among people with OUD are rising, placing a significant burden on patients. These findings suggest that early intervention and treatment of infections in this population are needed to prevent downstream harm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.