Evidence map›Paper›PMID 34711641›Full record

ArticleBMJ open respiratory research2021

Risk factors of mortality among patients hospitalised with COVID-19 in a critical care or hospital care unit: analysis of the French national medicoadministrative database.

Eric Ouattara, Amelie Bruandet, Aurélie Borde, Xavier Lenne, Florence Binder-Foucard, Maggie Le-Bourhis-Zaimi, Joris Muller, Pierre Tran Ba Loc, Fabienne Séguret, Sophie Tezenas du Montcel and 1 more

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In one paragraph

Article in BMJ open respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. COVID-19 in Patients with Pulmonary Hypertension: A National Prospective Cohort Study.American journal of respiratory and critical care medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eric OuattaraMedical Information Department, Medical information Analysis and Coordination Unit (UCAIM), University Hospital Centre Bordeaux, Bordeaux, France eric.ouattara@chu-bordeaux.fr.
Amelie BruandetMedical Information Department, Lille University Hospital Center, Lille, Hauts-de-France, France.
Aurélie BordeMedical Information Department, Medical information Analysis and Coordination Unit (UCAIM), University Hospital Centre Bordeaux, Bordeaux, France.
Xavier LenneMedical Information Department, Lille University Hospital Center, Lille, Hauts-de-France, France.
Florence Binder-FoucardPublic Health Department, University Hospitals Strasbourg, Strasbourg, Alsace, France.
Maggie Le-Bourhis-ZaimiMedical Information Department, Hospices Civils de Lyon, Lyon, Auvergne-Rhône-Alpes, France.
Joris MullerPublic Health Department, University Hospitals Strasbourg, Strasbourg, Alsace, France.
Pierre Tran Ba LocPublic Health Department, University Hospitals Strasbourg, Strasbourg, Alsace, France.
Fabienne SéguretUnit of Evaluation and Epidemiologic Studies on National Hospitalization Databases, Department of Epidemiology, Biostatistics and Medical Information, University Hospital Centre Montpellier, Montpellier, Languedoc-Roussillon, France.
Sophie Tezenas du MontcelSorbonne University, INSERM, Pierre Louis Epidemiology and Public Health Institute, Assistance Publique- Hopitaux de Paris, Medical Information Department, Pitié Salpêtrière - Charles Foix University Hospital, Paris, Île-de-France, France.
Véronique GilleronMedical Information Department, Medical information Analysis and Coordination Unit (UCAIM), University Hospital Centre Bordeaux, Bordeaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or a hospital care unit (HCU).

designRetrospective cohort analysis using the French national (

settingAny public or private hospital in France.

participants98 366 patients admitted with COVID-19 for more than 1 day during the first semester of 2020 were included. The underlying conditions were retrieved for all contiguous stays.

main outcome measuresIn-hospital mortality and associated risk factors were assessed using frailty Cox models.

resultsAmong the 98 366 patients included, 25 765 (26%) were admitted to a CCU. The median age was 66 (IQR: 55-76) years in CCUs and 74 (IQR: 57-85) years in HCUs. Age was the main risk factor of death in both CCUs and HCUs, with adjusted HRs (aHRs) in CCUs increasing from 1.60 (95% CI 1.35 to 1.88) for 46 to 65 years to 8.17 (95% CI 6.86 to 9.72) for ≥85 years. In HCUs, the aHR associated with age was more than two times higher. The gender was not significantly associated with death, aHR 1.03 (95% CI 0.98 to 1.09, p=0.2693) in CCUs. Most of the underlying chronic conditions were risk factors for death, including malignant neoplasm (CCU: 1.34 (95% CI 1.25 to 1.43); HCU: 1.41 (95% CI 1.35 to 1.47)), cirrhosis without transplant (1.41 (95% CI 1.22 to 1.64); 1.27 (95% CI 1.12 to 1.45)) and dementia (1.30 (95% CI 1.16 to 1.46); 1.07 (95% CI 1.03 to 1.12)).

conclusionThis analysis confirms the role of age as the major risk factor of death in patients with COVID-19 irrespective to admission to critical care and therefore supports the current vaccination policies targeting older individuals.

Indexed as

COVID-19AgedCritical CareHospitalsHumansMiddle AgedRetrospective StudiesRisk FactorsSARS-CoV-2COVID-19respiratory infectionviral infection

Identifiers

PMID34711641
PMCPMC8557246

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.