Evidence map›Paper›PMID 34711597›Full record

ArticleBMJ open2021

Protocol and statistical analysis plan for the Pragmatic Investigation of optimaL Oxygen Targets (PILOT) clinical trial.

Matthew W Semler, Jonathan D Casey, Bradley D Lloyd, Pamela G Hastings, Margaret Hays, Megan Roth, Joanna Stollings, John Brems, Kevin George Buell, Li Wang and 7 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537937 (Pragmatic Investigation of optimaL Oxygen Targets), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03537937 nacompletednot on this map

Pragmatic Investigation of optimaL Oxygen Targets (PILOT) Trial

TypeinterventionalSponsorVanderbilt University Medical CenterRan2018 to 2022Enrolled2,541ConditionsRespiratory FailureArmsLower SpO2 Target, Intermediate SpO2 Target, Higher SpO2 Target
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Response.Chest · 2022
    Article
  5. BMJ open · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Matthew W SemlerDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA matthew.w.semler@vumc.org.ORCID 0000-0002-7664-8263
Jonathan D CaseyDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Bradley D LloydDivision of Respiratory Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pamela G HastingsDivision of Respiratory Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Margaret HaysDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Megan RothDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Joanna StollingsDepartment of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John BremsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kevin George BuellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Li WangDepartment of Biostatistics, Vanderbilt University Schoool of Medicine, Nashville, TN, USA.
Christopher J LindsellDepartment of Biostatistics, Vanderbilt University Schoool of Medicine, Nashville, TN, USA.
Robert E FreundlichDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jonathan P WandererDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gordon R BernardDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Wesley H SelfDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Todd W RiceDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
PILOT Investigators and the Pragmatic Critical Care Research Group
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
Prevention and Early Treatment of Acute Lung Injury Clinical Trials NetworkU01HL123033 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICE, TODD W · 2014 to 2020
$2.4M
Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical TrialK23HL153584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASEY, JONATHAN DALE · 2020 to 2024
$900k
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients with High-Flow Nasal Cannula -the "I-CAN" studyK23HL148640 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREUNDLICH, ROBERT EDWARD · 2020 to 2024
$867k
Oxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854k
NCATS NIH HHS KL2 TR002245NCATS NIH HHS TL1 TR002244NCATS NIH HHS UL1 TR000445NHLBI NIH HHS K23 HL143053NHLBI NIH HHS K23 HL148640NHLBI NIH HHS K23 HL153584NHLBI NIH HHS U01 HL123033
6 · The paper itself

Abstract

introductionMechanical ventilation of intensive care unit (ICU) patients universally involves titration of the fraction of inspired oxygen to maintain arterial oxygen saturation (SpO METHODS AND ANALYSIS: The Pragmatic Investigation of optimaL Oxygen Targets (PILOT) trial is a prospective, unblinded, pragmatic, cluster-crossover trial being conducted in the emergency department (ED) and medical ICU at Vanderbilt University Medical Center in Nashville, Tennessee, USA. PILOT compares use of a lower SpO ETHICS AND DISSEMINATION: The trial was approved by the Vanderbilt Institutional Review Board. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences. TRIAL REGISTRATION NUMBER: The trial protocol was registered with ClinicalTrials.gov on 25 May 2018 prior to initiation of patient enrolment (ClinicalTrials.gov identifier: NCT03537937).

Indexed as

COVID-19HumansOxygenProspective StudiesRespiration, ArtificialSARS-CoV-2Oxygenaccident & emergency medicineadult intensive & critical careclinical trials

Identifiers

PMID34711597
PMCPMC8557284
OpenAlexW3209293982

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.