Evidence map›Paper›PMID 34711516›Full record

Observational studyReproductive biomedicine online2021

Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART.

Kamila Kolanska, Alice Hours, Laurie Jonquière, Emmanuelle Mathieu d'Argent, Yohann Dabi, Charlotte Dupont, Cyril Touboul, Jean-Marie Antoine, Nathalie Chabbert-Buffet, Emile Daraï

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Reproductive biomedicine online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  14. SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023
    Review
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  19. Observational
  20. COVID-19, Vaccination, and Female Fertility in the Czech Republic.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kamila KolanskaService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France; INSERM UMRS 938, Centre de Recherche Saint-Antoine, 27 rue Chaligny, PARIS cedex 12 75571, France. Electronic address: kamila.kolanska@aphp.fr.
Alice HoursService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France.
Laurie JonquièreService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France.
Emmanuelle Mathieu d'ArgentService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France.
Yohann DabiService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France.
Charlotte DupontINSERM UMRS 938, Centre de Recherche Saint-Antoine, 27 rue Chaligny, PARIS cedex 12 75571, France; Service de biologie de la reproduction-CECOS, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France.
Cyril TouboulService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France; INSERM UMRS 938, Centre de Recherche Saint-Antoine, 27 rue Chaligny, PARIS cedex 12 75571, France.
Jean-Marie AntoineService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France.
Nathalie Chabbert-BuffetService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France; INSERM UMRS 938, Centre de Recherche Saint-Antoine, 27 rue Chaligny, PARIS cedex 12 75571, France.
Emile DaraïService de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France; INSERM UMRS 938, Centre de Recherche Saint-Antoine, 27 rue Chaligny, PARIS cedex 12 75571, France.
Inserm · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

research questionDoes mild COVID-19 infection affect the ovarian reserve of women undergoing an assisted reproductive technology (ART) protocol?

designA prospective observational study was conducted between June and December 2020 at the ART unit of Tenon Hospital, Paris. Women managed at the unit for fertility issues by in-vitro fecundation, intracytoplasmic sperm injection (IVF/ICSI), fertility preservation, frozen embryo transfer or artificial insemination, and with an anti-Müllerian hormone (AMH) test carried out within 12 months preceding ART treatment, were included. All the women underwent a COVID rapid detection test (RDT) and AMH concentrations between those who tested positive (RDT positive) and those who tested negative (RDT negative).

resultsThe study population consisted of 118 women, 11.9% (14/118) of whom were COVID RDT positive. None of the tested women presented with a history of severe COVID-19 infection. The difference between the initial AMH concentration and AMH concentration tested during ART treatment was not significantly different between the COVID RDT positive group and COVID RDT negative group (-1.33 ng/ml [-0.35 to -1.61) versus -0.59 ng/ml [-0.15 to -1.11], P = 0.22).

conclusionA history of mild COVID-19 infection does not seem to alter the ovarian reserve as evaluated by AMH concentrations. Although these results are reassuring, further studies are necessary to assess the effect of COVID-19 on pregnancy outcomes in women undergoing ART.

Indexed as

Ovarian ReserveAdultAnti-Mullerian HormoneCase-Control StudiesCOVID-19FemaleHumansProspective StudiesReproductive Techniques, AssistedAnti-Mullerian HormoneAMHARTCOVIDOvarian reserve

Identifiers

PMID34711516
PMCPMC8432972
OpenAlexW3200211820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.