Evidence map›Paper›PMID 34711401›Full record

ReviewTrends in neurosciences2021

Rethinking stress resilience.

Seema Bhatnagar

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Prefrontal corticotropin-releasing factor promotes resilience to social stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Seema BhatnagarStress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, The Perelman School of Medicine at the University of Pennsylvania, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA. Electronic address: bhatnagars@chop.edu.

Funding

Development of Defensive Behavior and Social Stress ConsequencesR01MH093981 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BHATNAGAR, SEEMA · 2011 to 2018
$3.7M
Sex differences in orexinsR01MH109975 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BHATNAGAR, SEEMA · 2016 to 2020
$2.1M
Stress, CRF and Locus Coeruleus-Cortical Network ActivityR01MH111751 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BHATNAGAR, SEEMA · 2016 to 2020
$2.1M
Orexins/hypocretins and resilience to stressR21MH102735 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BHATNAGAR, SEEMA · 2014 to 2015
$462k
NIMH NIH HHS R01 MH093981NIMH NIH HHS R01 MH109975NIMH NIH HHS R01 MH111751NIMH NIH HHS R21 MH102735
6 · The paper itself

Abstract

Resilience to stressful life events has received considerable attention in both clinical and preclinical studies. A number of neural substrates have been identified as putatively mediating resilience to stress. However, there remains considerable diversity in how resilience is defined and studied. This article aims to examine how resilience is defined and conceptualized in social psychology, public health, and related fields, to better inform the understanding of stress resilience in the neurobiological context, and to differentiate resilience from other patterns of response to stressful experiences. An understanding of resilience through the lens of clinical and applied sciences is likely to lead to the identification of more robust and reproducible neural substrates, though many challenges remain.

Indexed as

Resilience, PsychologicalStress Disorders, Post-TraumaticHumansNeurobiologyStress, Psychologicalbraininflammationneural substratesPTSDsex differences

Identifiers

PMID34711401
PMCPMC8616827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.