Evidence map›Paper›PMID 34711238›Full record

ArticleJournal of neuroinflammation2021

Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection.

Mohammad Harun Rashid, Nicklaus A Sparrow, Faizan Anwar, Gena Guidry, Ambart E Covarrubias, Haoming Pang, Chandrakumar Bogguri, S Ananth Karumanchi, Shouri Lahiri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Animal models of delirium: a narrative review.Translational psychiatry · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mohammad Harun RashidDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nicklaus A SparrowDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Faizan AnwarDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Gena GuidryDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ambart E CovarrubiasDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Haoming PangDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Chandrakumar BogguriDepartment of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
S Ananth KarumanchiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shouri LahiriDepartments of Neurology, Neurosurgery, and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA. shouri.Lahiri@csmc.edu.ORCID http://orcid.org/0000-0002-5469-6467
Cedars-Sinai Medical Center · US

Funding

Neuropathology of Cognitive Impairment in Critical IllnessR03AG064106 · NIA · CEDARS-SINAI MEDICAL CENTER · PI LAHIRI, SHOURI · 2019 to 2020
$255k
NIA NIH HHS R03 AG064106NIA NIH HHS R03AG064106
6 · The paper itself

Abstract

backgroundUrinary tract infection (UTI) is frequently implicated as a precipitant of delirium, which refers to an acute confusional state that is associated with high mortality, increased length of stay, and long-term cognitive decline. The pathogenesis of delirium is thought to involve cytokine-mediated neuronal dysfunction of the frontal cortex and hippocampus. We hypothesized that systemic IL-6 inhibition would mitigate delirium-like phenotypes in a mouse model of UTI.

methodsC57/BL6 mice were randomized to either: (1) non-UTI control, (2) UTI, and (3) UTI + anti-IL-6 antibody. UTI was induced by transurethral inoculation of 1 × 10

resultsCompared to non-UTI control mice, mice with UTI demonstrated significantly greater impairments in frontal and hippocampus-mediated behaviors, specifically increased thigmotaxis in Open Field (p < 0.05) and reduced spontaneous alternations in Y-maze (p < 0.01), while treatment of UTI mice with systemic anti-IL-6 fully reversed these functional impairments. These behavioral impairments correlated with frontal and hippocampal neuronal CC3 changes, with significantly increased frontal and hippocampal CC3 in UTI mice compared to non-UTI controls (p < 0.0001), and full reversal of UTI-induced CC3 neuronal changes following treatment with systemic anti-IL-6 antibody (p < 0.0001). Plasma IL-6 was significantly elevated in UTI mice compared to non-UTI controls (p < 0.01) and there were positive and significant correlations between plasma IL-6 and frontal CC3 (r

conclusionsThese data provide evidence for a role for IL-6 in mediating delirium-like phenotypes in a mouse model of UTI. These findings provide pre-clinical justification for clinical investigations of IL-6 inhibitors to treat UTI-induced delirium.

Indexed as

Disease Models, AnimalPhenotypeAnimalsAntibodies, MonoclonalBrainDeliriumFemaleInterleukin-6Interleukin-6 InhibitorsMaze LearningMiceMice, Inbred C57BLUrinary Tract InfectionsAntibodies, MonoclonalInterleukin-6Interleukin-6 InhibitorsDeliriumIL-6IL-6 inhibitionNeuroinflammationNeuronUTI

Identifiers

PMID34711238
PMCPMC8554965
OpenAlexW3210321175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.