ArticlePharmaceutical biology2021
The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats.
Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Individuals with a history of Cesarean or Induced abortion combined with allergies will significantly increase their risk of endometriosis: A prospective case-control study.Pakistan journal of medical sciences · 2026Article
- Hormonal regulation and reproductive improvement with adjunctive Zishen Yutai Pill in polycystic ovary syndrome: a systematic review with meta-analysis.Frontiers in reproductive health · 2025Review
- Zishen Yutai Pills Promote Angiogenesis at the Maternal-Fetal Interface in Recurrent Spontaneous Abortion Mice by Regulating miR-187/VEGF Axis.Drug design, development and therapy · 2024Article
- Neutral effect of Zishen Yutai Pill on frozen-thawed embryo transfer: a propensity score matching study.Frontiers in endocrinology · 2024Article
- Regulatory effects of Zishen Yutai Pill on endometrial epithelial response in vitro in immunology microenvironment.Heliyon · 2023Article
- Identification of potential quality markers of Zishen Yutai pill based on spectrum-effect relationship analysis.Frontiers in pharmacology · 2023Article
- The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors.Evidence-based complementary and alternative medicine : eCAM · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAbortions damage the endometrium in women. Currently, therapeutic options for endometrial recovery are limited. Zishen Yutai Pill (ZYP) was found to promote endometrial blood supply as a traditional Chinese medicine. However, whether ZYP promotes endometrial recovery post-abortion has not yet been explored.
objectiveThis study evaluated the role of ZYP in rat endometrial recovery after induced abortion and explored its mechanism of action. MATERIALS AND
methodsSprague-Dawley rats were divided into three groups: no-operation group, control group, and ZYP group. The rats in the control and ZYP group were induced abortion, and then treated with normal saline or ZYPs, respectively, for 1-3 oestrous cycles. Morphological changes in the endometrium were examined. Expression levels of the factors related to endometrial recovery were analyzed. The duration of this study was almost seven months.
resultsThe endometrial thickness (7.3 ± 0.17 mm) and number of glands (5.5 ± 0.20) increased significantly in the ZYP group compared with those in the control group (5.5 ± 0.15 mm and 3.5 ± 0.18; DISCUSSION AND
conclusionZYPs accelerate endometrial recovery and restored fertility in rats, suggesting its potential to promote human endometrial repair.
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