SynthesisThe Journal of neuropsychiatry and clinical neurosciences2022
Autonomic, Endocrine, and Inflammation Profiles in Functional Neurological Disorder: A Systematic Review and Meta-Analysis.
Synthesis in The Journal of neuropsychiatry and clinical neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The neurobiology of functional neurological disorders characterised by impaired awareness.Frontiers in psychiatry · 2023Pooled it
- Developmental trauma in functional motor disorder: the mediating roles of affective symptoms and multimorbidity.Psychological medicine · 2026Article
- Stress-related neuroplasticity and developmental vulnerability in functional neurological disorder: from adverse experience to maladaptive overlearning.Frontiers in molecular neuroscience · 2026Review
- The heartbeat evoked potential and the prediction of functional seizure semiology.Brain communications · 2026Article
- Improved outcomes for patients with autonomic movement disorders originally evaluated for psychogenic non-epileptiform spells.Frontiers in neurology · 2026Article
- Attenuated heartbeat-evoked potentials in functional neurological disorder.Brain communications · 2026Article
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Relationships between brain functional connectivity and resting cardiac autonomic profiles in functional neurological disorder: A pilot study.NeuroImage. Clinical · 2026Article
- Momentary predictors of dissociation in functional neurological disorder: an ecological momentary assessment-based pilot study.Frontiers in psychiatry · 2026Article
- Iatrogenic harm in functional neurological disorder.Brain : a journal of neurology · 2025Review
- The adjunct role of pharmacotherapy in multimodal treatment of paediatric functional neurological disorder.Frontiers in psychiatry · 2025Article
- Pathophysiology of functional neurological disorder for the general neurologist.BMJ neurology open · 2025Review
- Predictive Processing and the Pathophysiology of Functional Neurological Disorder.Current topics in behavioral neurosciences · 2025Review
- Real-time biopsychosocial antecedents and correlates of functional neurological symptoms in daily life: A pilot remote monitoring technology study.Psychiatry research · 2024Article
- Functional Neurological Disorder and Autism Spectrum Disorder: A Complex and Potentially Significant Relationship.Brain and behavior · 2024Review
- Locus coeruleus co-activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study.Epilepsia open · 2024Article
- Biomarkers and Rehabilitation for Functional Neurological Disorder.Journal of personalized medicine · 2024Review
- High Prevalence of Psychological Comorbidities and Functional Neurological Symptoms in Women With Urinary Retention.The Journal of urology · 2024Article
- Sensory Processing Difficulties and Occupational Therapy Outcomes for Functional Neurological Disorder: A Retrospective Cohort Study.Neurology. Clinical practice · 2024Article
- Unravelling the influence of affective stimulation on functional neurological symptoms: a pilot experiment examining potential mechanisms.Journal of neurology, neurosurgery, and psychiatry · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveFunctional neurological disorder (FND) is a core neuropsychiatric condition. To date, promising yet inconsistently identified neural circuit profiles have been observed in patients with FND, suggesting that gaps remain in our systems-level neurobiological understanding. As such, other important physiological variables, including autonomic, endocrine, and inflammation findings, need to be contextualized for a more complete mechanistic picture.
methodsThe investigators conducted a systematic review and meta-analysis of available case-control and cohort studies of FND. PubMed, PsycINFO, and Embase databases were searched for studies from January 1, 1900, to September 1, 2020, that investigated autonomic, endocrine, and inflammation markers in patients with FND. Sixty-six of 2,056 screened records were included in the review, representing 1,699 patients; data from 20 articles were used in the meta-analysis.
resultsFindings revealed that children and adolescents with FND, compared with healthy control subjects (HCs), have increased resting heart rate (HR); there is also a tendency toward reduced resting HR variability in patients with FND across the lifespan compared with HCs. In adults, peri-ictal HR differentiated patients with functional seizures from those with epileptic seizures. Other autonomic and endocrine profiles for patients with FND were heterogeneous, with several studies highlighting the importance of individual differences.
conclusionsInflammation research in FND remains in its early stages. Moving forward, there is a need for the use of larger sample sizes to consider the complex interplay between functional neurological symptoms and behavioral, psychological, autonomic, endocrine, inflammation, neuroimaging, and epigenetic/genetic data. More research is also needed to determine whether FND is mechanistically (and etiologically) similar or distinct across phenotypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.