Evidence map›Paper›PMID 34711009›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2021

TGF-Β1 & PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis and HCC in Egyptian Patients with HCV-Related Liver Cirrhosis.

Azhar Mohamed Nomair, Lamia Said Kandil, Hanan Mohamed Nomeir, Noha Said Kandil

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PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. TGF-Β1, PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis: Correspondence.Asian Pacific journal of cancer prevention : APJCP · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Azhar Mohamed NomairDepartment of Chemical Pathology, Medical Research Institute, Alexandria University, Egypt.
Lamia Said KandilDepartment of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University, Egypt. Lecturer in the School of Biological Sciences, Faculty of Science, University of East Anglia, UK.
Hanan Mohamed NomeirDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria University, Egypt.
Noha Said KandilDepartment of Chemical Pathology, Medical Research Institute, Alexandria University, Egypt.
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe clinical outcomes of hepatitis C virus (HCV) infection and its sequelae including liver cirrhosis and hepatocellular carcinoma (HCC) are greatly affected by host genetic factors; however, the possible mechanisms are still largely unclear. This work aimed to assess transforming growth factor-β1 (TGF-β1), and patatin-like phospholipase domain containing-protein 3 (PNPLA3) genetic variants as risk factors for hepatic fibrosis and hepatocellular carcinoma (HCC) in Egyptian patients with HCV-related liver cirrhosis.

methodsSeventy HCV-related liver cirrhosis patients (Total cirrhosis) who were divided into two groups; 34 patients with HCC (HCC group), and 36 patients without HCC (LC group) and 20 healthy volunteers (control group) were included. Routine laboratory investigations and imaging studies were determined. TGF-β1 (Arg25Pro; 915G>C) and PNPLA3 (I148M; C>G) variants were evaluated using real-time polymerase chain reaction (real-time PCR).

resultsHCC group showed a significantly higher GG genotype distribution of TGF-β1 (Arg25Pro) than the LC group (P= 0.008, OR: 7.083, CI 95%: 1.422 - 35.282). The distributions of GG genotype (P= 0.047) and G allele (P= 0.002, OR: 4.395, CI 95%: 1.622 - 11.911) of PNPLA3 (I148M) were significantly higher in total cirrhosis patients than controls.

conclusionTGF-β1 (Arg25Pro) GG variant may be associated with HCC risk in HCV-related liver cirrhosis patients, while PNPLA3 (I148M) GG variant may be associated with cirrhosis development but not HCC risk in HCV-related liver cirrhosis patients.

Indexed as

Genetic VariationAcyltransferasesCarcinoma, HepatocellularCase-Control StudiesCodonEgyptFemaleHepatitis CHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedPhospholipases A2, Calcium-IndependentPolymorphism, Single NucleotideRiskAcyltransferasesCodonPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1gene polymorphismHCCHCVLiver fibrosis

Identifiers

PMID34711009
PMCPMC8858238
OpenAlexW3209720924

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.